Hepatic Gene Expression Profiles Differentiate Steatotic and Non-steatotic Grafts in Liver Transplant Recipients

Conclusions: While there is a certain overlap between the results of the current study and published transcriptomic profiles of non-transplanted livers with steatosis, we have identified discrete characteristics of the non-alcoholic fatty liver disease in liver grafts potentially utilizable for the establishment of predictive signature. Introduction Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in industrialized countries, its prevalence being estimated at 19–31.3% (1). It encompasses a range of conditions that are thought to arise from fatty liver (simple steatosis) through non-alcoholic steatohepatitis (NASH), which refers to findings on liver biopsy reflecting typical metabolic and inflammatory changes (fat-related inflammation) with or without fibrosis in the absence of significant alcohol consumption (2, 3). NASH may develop into liver cirrhosis and hepatocellular carcinoma. Although NAFLD itself may be rather benign in the majority of patients, it is associated with increased specific (liver-related) mortality (4) and represents a substantial risk particularly for both fatal and non-fatal adverse cardiovascular events (5, 6) and chronic kidney disease (7). The pathogenesis of NAFLD is multifactorial and multiple genetic and behavioral factors were identified to contribute to hepatic mishandling of fatty acids and carbohydrates as energy sources, as recently reviewed in detail. The overload of fatty acids in hepatocytes...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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Bayer's finerenone meets primary endpoint in Phase III FIDELIO-DKD renal outcomes study in patients with chronic kidney disease and type 2 diabetesFinerenone significantly reduced the combined primary endpoint of chronic kidney disease progression, kidney failure or kidney death versus placebo when added to standard of care / Finerenone significantly reduced the combined key secondary endpoint of cardiovascular death or non-fatal cardiovascular events / Chronic kidney disease impacts 4 in 10 patients with type 2 diabetes and is a deadly condition that is underrecognized / Finerenone is the first investigational non-steroid...
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Publication date: Available online 9 July 2020Source: The Journal of Foot and Ankle SurgeryAuthor(s): Ahmet Emin Okutan, Muhammet Salih Ayas, Kerim Öner, Ahmet U─čur Turhan
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Authors: Dutra JDM, Lisboa QC, Ferolla SM, Carvalho CMML, Mendes CCM, Ferrari TCA, Couto CA Abstract Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histo...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
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Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p 
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Publication date: Available online 9 July 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Lucia La Sala, Livio Luzi, Antonio E. Pontiroli
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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The Food and Drug Administration has added more hand sanitizers to its growing list of products that contain wood alcohol, which is toxic if absorbed through the skin.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 8 July 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Chih-Lin Lin, Kuo-Chih Tseng, Kuan-Yang Chen, Li-Ying Liao, Jia-Horng Kao
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
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