Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

Conclusion: BUP and metabolites are not substrates of the major hepatic transporters tested and thus these hepatic transporters likely do not play a role in the overall disposition of the drug. Our results also suggest that caution should be taken when using the model CHO and HEK293 cell lines to evaluate potential roles of transporters in drug disposition.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research