USP7: Novel Drug Target in Cancer Therapy

Conclusion and Future Perspectives This review illustrates our current knowledge of USP7, including its source and characterization, structure, binding partners and substrates in various biological processes. Besides, how USP7 regulates various aspects of a cell under both normal and pathological states are elaborated in detail. As the processes of ubiquitination and deubiquitination are extremely dynamic and context-specific, a series of studies have linked USP7 to different cancers. The biology, particularly the immune oncology mechanisms, reveal that USP7 inhibitors would be useful drugs, thus it is vital to develop highly selective and specific inhibitors of USP7. The association of USP7 with several canonical signaling pathways still needs characterized in order to search new targets and regulatory mechanisms. Last but not least, USP7 may be a promising target for cancer therapy and it therefore merits further studies. Author Contributions ZW discusses the structure of USP7, the viral protein targets of USP7, the DNA damage substrates of USP7 and conclusion. WK talks about the introduction, immune function of USP7, Wnt/β-catenin signaling pathway, and NF-κB signaling pathway. YY illustrates oncoproteins and tumor suppressor proteins. JP states about the epigenetics substrates of USP7. HR talks about the NOTCH signaling pathway. ZS and YZ provide expertise and feedback. HL provides funding. Funding This work was supported by National Natural Science Founda...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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