Extract of Plantago asiatica L. Seeds Ameliorates Hypertension in Spontaneously Hypertensive Rats by Inhibition of Angiotensin Converting Enzyme

In conclusion, we have demonstrated that PASE has the long-acting anti-hypertension effect and ACE inhibition may be the mechanism of PASE antihypertensive activity. Phenylethanoid glycosides including isoacteoside, plantamajoside and acteoside, might be considered as major active compounds of PASE for the antihypertensive effect in SHRs. Meanwhile, PASE also protects organ injury including LVH, vascular remodeling and renal dysfunction. Our results suggest that PASE may be a potential therapy for blood pressure controlling and cardiovascular disease prevention. Author Contributions MQ, Q-MY, Z-TW, and LY developed the conception and design of the study. R-CT, MQ, Q-MY, P-FL, D-DW, and J-PL performed the experiments and analyzed the data. Z-TW and LY revised the manuscript. All authors contributed to the final manuscript and approved it for publication. Funding This study was supported by National Natural Science Foundation (81403070) and the Program of Shanghai Academic/Technology Research Leader (17XD1403500). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2019.00403/full#supplementary-material References Bai, R. R., Xiao-Ming, W. U., and Jin-Yi, X. U. (2015). Current ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research