Efficacy Assessment of a Topically Applied Nitric –Zinc Complex Solution for the Treatment of External Ano-genital Warts in 100 Patients

The objective of this study was to investigate the efficacy and tolerability of NZC in the treatment of AGWs.MethodsPatients attending for AGWs between September 2016 and February 2018 were retrospectively studied. They received at least one NZC application for a maximum of four treatments (V0, V1, V2, V3) with average intervals of 25  days between sessions. Recurrences were evaluated at 3 and 6 months after clearance.ResultsOne hundred patients (70 males, 30 females) with a mean age of 36.39  years were studied. The total number of AGWs diagnosed at the baseline visit (V0) in all patients was 418 with a mean of 4.18 AGWs per patient. A wart cure rate of 92% was observed in ≤ 4 treatment sessions (383 lesions cured at visit 4, V4, out of 418 lesions at baseline), with a cure rate of 49% with only one NZC application. Complete clearance was observed in 25, 52, 72 and 84% of patients at V1, V2, V3 and V4, respectively. Relapses were observed in 29% of patients at 3 months and in 5% at 6 months. Of note, patients with ≤ 5 AGWs at V0 showed better clearance results than patients with >  5 lesions (p 
Source: Dermatology and Therapy - Category: Dermatology Source Type: research

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Genital human papilloma virus (HPV) infection is the most common sexually transmitted infection. It may be asymptomatic or manifests as benign or malignant lesions. The pathogenesis of HPV infection is not completely elucidated; in most cases spontaneous viral clearance occurs. In our study we have investigated the effect of HPV infection on the balance between oxidants and antioxidants in patients with genital warts. We have determined the serum levels of soluble receptor for advanced glycation end products (sRAGE), total oxidant status (TAS) and total antioxidant status (TOS) in 15 patients with genital warts and 28 healthy subjects.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research
AbstractIn the U.S. there is an epidemic of sexually transmitted diseases (STIs). One of the most prevalent STIs is the Human Papillomavirus (HPV). Certain high risk strains of HPV are believed to cause virtually all cervical cancers, over 90% of anal cancers, 70% of oropharyngeal cancers, and the majority of anal  genital warts. HPV is preventable through vaccination and is available for both men and women. Several educational interventions have been employed, yet baseline awareness and knowledge related to HPV and 9vHPV remains relatively low among young men. What is not known is the most effective method for provid...
Source: Journal of Community Health - Category: International Medicine & Public Health Source Type: research
Anal warts develop due to the human papillomavirus. They can cause itching, bleeding, and other symptoms. Treatment may involve topical medications, liquid nitrogen, or surgical removal. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Sexual Health / STDs Source Type: news
An analysis covering 66 million young people has found plummeting rates of precancerous lesions and genital warts after vaccination against the human papillomavirus.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Human Papillomavirus (HPV) Women and Girls Vaccination and Immunization Cervical Cancer Sexually Transmitted Diseases Warts Gardasil (Vaccine) Third World and Developing Countries Centers for Disease Control and Prevention Lancet, The (J Source Type: news
CONCLUSIONS: These findings highlight the need for educational campaigns regarding HPV infection, its potential as a cervical cancer agent and the forms of prevention available.RESUMO OBJETIVO: O papilomav írus humano (HPV) é o vírus sexualmente transmissível mais prevalente no mundo, estando a infecção por este agente associada a um aumento do risco do câncer de colo uterino. A abordagem mais eficaz para o controle desse tipo de câncer continua sendo a triagem por meio do exame preventivo (Pa panicolaou). Este estudo analisa o conhecimento de estudantes universit&aacut...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
Conclusions Human immunodeficiency virus–positive men have a high burden of genital HPV infection and AGW. The ART and HPV vaccine could reduce this burden.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Original Studies Source Type: research
In this study it was assumed that there was no immunity following resolution of natural infection. The modeling demonstrated that a vaccine of moderate efficacy could have a significant impact on the prevalence of gonorrhea if strategically implemented (23). While encouraging it does, of course, depend on the availability of a vaccine. From Ecological Data to Evidence The epidemiological evidence from Cuba, Brazil, and New Zealand demonstrates that N. meningitidis OMV vaccines are possibly able to provide some broader protection against meningococcal disease (17, 24), particularly in older children and adults (25). These...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions These findings suggest that the degree of HPV vaccine impact has varied substantially by age and sex. Achieving the full prevention potential of HPV vaccines will likely require greater coverage among both females and males. Post-licensure estimates of effectiveness demonstrate the real-world benefit of the vaccine.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Review Source Type: research
Conclusions: Genotyping of HPV provides significant clinical information regarding this family of viruses that play a role in the aetiology of a variety of genital cancers, as some of these malignancies are now considered preventable due to recent development of vaccines. We believe that our results may provide guidance on future vaccination programs in our country. PMID: 30858783 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Human papillomavirus (HPV) is a very common sexually transmitted infection. Some types of HPV can cause genital warts, which can develop on the vulva, vagina, and cervix. Learn more about the causes, treatment, and prevention of genital warts in women here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Sexual Health / STDs Source Type: news
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