Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma

In this study, we evaluated the therapeutic benefit of combining the TAB004 antibody with Liposomal-MSA-IL-2 in immune competent and human MUC1 transgenic (MUC1.Tg) mouse models of PDA and investigated the associated immune responses. Treatment with TAB004 + Lip-MSA-IL-2 resulted in significantly improved survival and slower tumor growth compared to controls in MUC1.Tg mice bearing an orthotopic PDA.MUC1 tumor. Similarly, in the spontaneous model of PDA that expresses human MUC1, the combination treatment stalled the progression of pancreatic intraepithelial pre-neoplastic (PanIN) lesion to adenocarcinoma. Treatment with the combination elicited a robust systemic and tumor-specific immune response with (a) increased percentages of systemic and tumor infiltrated CD45+CD11b+ cells, (b) increased levels of myeloperoxidase (MPO), (c) increased antibody-dependent cellular cytotoxicity/phagocytosis (ADCC/ADCP), (d) decreased percentage of immune regulatory cells (CD8+CD69+ cells), and (e) reduced circulating levels of immunosuppressive tMUC1. We report that treatment with a novel antibody against tMUC1 in combination with a unique formulation of IL-2 can improve survival and lead to stable disease in appropriate models of PDA by reducing tumor-induced immune regulation and promoting recruitment of CD45+CD11b+ cells, thereby enhancing ADCC/ADCP. Introduction Pancreatic ductal adenocarcinoma (PDA) has the poorest prognosis of all malignancies with more than 260,000 deaths ann...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Abstract Objective: The main goal of our study was to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways. Methods: We enrolled 38 patients with ≥ 45 years old undergoing surgery for abdominal aortic aneurysm or peripheral artery disease under general or regional anesthesia and who were hospitalized at least one night after the procedure. Patients undergoing carotid artery surgery and those who had acute bypass graft thrombosis, cancer, renal failure defined as estimated glomerular filtration rate
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Salazar-Mejía CE, Wimer-Castillo BO PMID: 31326096 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Nagpal SDS, Singh NP, Mishra P, Singh A Abstract Rheumatoid arthritis (RA) is a common rheumatological condition affecting the joints and has a wide range of extra-articular manifestations. A 69 year old male, known case of rheumatoid arthritis presented to our OPD with right lower limb redness and swelling, and left axillary lymph node swelling. Lymph node biopsy revealed a high grade diffuse large B-cell lymphoma with co-expression of c-myc and bcl-2 (double expressor). RA increases the risk of both Hodgkin's lymphoma (HL) and non-Hodgkin's Lymphoma (NHL). The association with diffuse large B-cell lympho...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: In healthy Indians ≥50 years, ZOSTAVAX was well tolerated and resulted in expected VZV-specific antibody titer levels at 6 weeks post-vaccination. PMID: 31325263 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Most common etiology of PRS is ANCA positive vasculitis in India. With high degree of suspicion for DAH in patients presenting with haemoptysis, breathlessness and alveolar opacities in chest x-ray and carefully investigating by simple urine examination for evidence of GN, timely diagnosis of PRS can be made. With timely appropriate treatment survival is 68%. Patients with PRS due to leptospirosis or dengue have features suggestive of underlying disease (like icterus with raised bilirubin but
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Krishnan M, N B, K T, S S PMID: 31324093 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Publication date: Available online 21 July 2019Source: Food ControlAuthor(s): Alexandros Ch Stratakos, Umer Zeeshan Ijaz, Patrick Ward, Mark Linton, Carmel Kelly, Laurette Pinkerton, Pam Scates, Jane McBride, Ioan Pet, Adriana Criste, Ducu Stef, Jillian M. Couto, William T. Sloan, Nick Dorrell, Brendan W. Wren, Lavinia Stef, Ozan Gundogdu, Nicolae CorcionivoschiAbstractListeriosis is an important food-borne disease responsible for high rates of morbidity and mortality. L. monocytogenes has been the cause of several foodborne outbreaks and its ability to adapt and survive in a wide range of environmental conditions makes er...
Source: Food Control - Category: Food Science Source Type: research
Conclusions: the results showed an increased trend of elderly women dying of breast cancer in the region and with higher levels in the micro-regions with better indicators on living conditions.Resumo Objetivos: avaliar a rela ção entre as taxas corrigidas de mortalidade por câncer de mama e indicadores de condições de vida das idosas das microrregiões do Nordeste brasileiro. Métodos: adotou-se um estudo ecológico nos anos de 2010 e 2015 para as 188 microrregiões do Nordeste utilizando a modelagem de equações estruturais. Os dados de populaç&...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
In July, Alaska Governor Michael Dunleavy slashed approximately 41 percent or $130 million from the University of Alaska system budget, a move that will have long-lasting and significant impacts on research and education throughout the state and potentially the United States. Governor Dunleavy used his line item veto authority to gut the budget of the University of Alaska system, which will likely result in the termination of research and education programs. “A preliminary rough estimate is that we would need to reduce 1,300 faculty and staff across the university system,” said Jim Johnson, President of the U...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
On July 11, 2019, the National Science Foundation (NSF) issued a new personnel policy that outlines the obligations of NSF personnel and Intergovernmental Personnel Act (IPA) assignees with respect to foreign government talent recruitment programs. The policy was announced in conjunction with a “Dear Colleague Letter” on research protections from NSF Director France Cordova. According to NSF, open scientific exchange is facing a challenge from foreign government talent recruitment programs, which “disregard intellectual and other proprietary rights, and reflect foreign state-sponsored attempts to acquire...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
More News: Adenocarcinoma | Allergy & Immunology | Avandia | Avastin | Biotechnology | Brain | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer Vaccines | Carcinoma | Carcinoma in Situ | Chemistry | Chemotherapy | Clinical Trials | Colon Cancer | Colorectal Cancer | Dermatitis | Dermatology | Eloxatin | Environmental Health | Epithelial Cancer | Erbitux | Funding | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Grants | Head and Neck Cancer | Hematology | HER2 | Herceptin | Hodgkin's Disease | Immunotherapy | Laboratory Medicine | Lymphoma | Medical Ethics | Melanoma | Men | Milk | Neoadjuvant Chemotherapy Therapy | Neoadjuvant Therapy | Neurology | Neurosurgery | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Penicillin | PET Scan | Rituxan | Skin | Skin Cancer | Statistics | Stem Cell Therapy | Stem Cells | Study | Tamoxifen | Toxicology | USA Health | Usher Syndrome | Vaccines | Veterinary Vaccinations | Yervoy