Subclinical Lesions of the Primary Clinical Target Volume Margin in Esophageal Squamous Cell Carcinoma and Association With FDG PET/CT

Conclusions: To cover 94.5% of ESCC subclinical lesions in the CTVp, a 3-cm margin along the cranial-caudal axis should be added to the primary gross tumor volume as defined by FDG-PET/CT, as well as a cutoff SUVmax value of 2.5. Although preoperative FDG PET/CT images may not reveal lesions directly, the SUVmax and MTV measurements together could predict their presence. Background Esophageal carcinoma often occurs as squamous cell carcinoma (ESCC), a highly aggressive malignancy with a poor prognosis worldwide. The incidence rates of ESCC are particularly high in China (1). Most patients with ESCC have locally advanced disease (2, 3). Important treatment strategies for locally advanced ESCC include neoadjuvant chemoradiation and definitive chemoradiation or radiation therapy. However, the overall survival and local control rates remain unsatisfactory—the 2-year survival rate is merely 30–40%, and the local relapse rate may reach up to 50% (4–6). In ESCC radiotherapy, an accurate delineation of the primary clinical target volume (CTVp) importantly influences the success of the outcome, with higher local regional control, and less toxicity. Wu et al. suggested that CTVp is generally a 3–4 cm superior and inferior expansion of the gross tumor volume (GTV) and a 1 cm radial expansion, according to an expert consensus (7). However, when basing the CTVp on the size of the primary gross tumor, there are no established or standard guidelines for how ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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In this study we explored the use of a natural compound rubusoside (RUB) as a solubilizer to enhance the solubility of a fluorescence-labeled C6-Ceramide (NBD C6-Ceramide) and to characterize its pharmacokinetics and tissue distribution in an animal model. RUB significantly enhanced the solubility of NBD C6-Ceramide by forming nanomicelles, and efficiently delivered NBD C6-Ceramide in rats by oral and intravenous administration. RUB loaded 1.96% of NBD C6-Ceramide in the nanomicelles and solubilized it to a concentration of 3.6 mg/mL in water. NBD C6-Ceramide in nanomicelles remained stable in aqueous solutions, all...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Authors: McAlpine K, Breau RH PMID: 31818928 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
Publication date: January 2020Source: International Journal of Educational Development, Volume 72Author(s): Lunxuan Sun, M. Najeeb Shafiq, Maureen McClure, Sisi GuoAbstractWe investigate the educational and psychological benefits from participating in private supplementary tutoring in Mainland China. We use the 2013–2015 China Education Panel Survey data on junior high school students and a difference-in-difference and propensity score matching research design. Our results show that private tutoring is positively associated with higher English scores for rural students only. For all students and across most sub-group...
Source: International Journal of Educational Development - Category: Child Development Source Type: research
Publication date: Available online 11 December 2019Source: The Crop JournalAuthor(s): Xueqin Liu, Jianbo He, Yufeng Wang, Guangnan Xing, Yan Li, Shouping Yang, Tuanjie Zhao, Junyi GaiAbstractA fast-growing protein and oil crop, soybean was domesticated in ancient China and disseminated early in Asia and afterwards to other continents, in particular the Americas in recent centuries. After adaptation, locally developed landraces and cultivars formed a diversity of geographic-populations. In an investigation of their phylogeographic features, marker-derived traits were combined with geography-related photo- and temperature-se...
Source: The Crop Journal - Category: Food Science Source Type: research
Publication date: Available online 10 December 2019Source: The Crop JournalAuthor(s): Jianning He, Yu Shi, Junye Zhao, Zhenwen YuAbstractSustainable agriculture in the Huang–Huai–Hai Plain of China is threatened by subsoil compaction and the decline of winter wheat productivity induced by inappropriate tillage regimes. We investigated the effects of optimizing the tillage regime on grain filling and its relationship with flag leaf senescence post-anthesis in winter wheat. Four treatments were compared: rotary tillage, strip rotary tillage, strip rotary tillage with a 2-year subsoiling interval (STS), and conven...
Source: The Crop Journal - Category: Food Science Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Food Composition and AnalysisAuthor(s): Afsaneh Mohajer, Abbas Norouzian Baghani, Parisa Sadighara, Kiandokht Ghanati, Shahrokh NazmaraAbstractIn this current study, the contents of heavy metals including Pb, As, Cr, Cd, Zn, Cu, and Mn in imported rice bran oil in Iran were investigated with microwave digestion method based on an inductively coupled plasma optical emission spectrometry system (ICP-OES). The concentrations range of Pb, Cr, Cd, As, Zn, and Cu in rice bran oil samples were measured as 0.066 - 0.30, 0.008 - 0.014, 0.005 - 0.01, 0.047- 0.01, ...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
In this study, the effects of the addition of various polysaccharides (konjac gum, gellan gum, and curdlan gum) on the rheological and textural properties of calcium sulfate-induced soy protein isolate gels were investigated. The incorporation of konjac gum and curdlan gum at 0.3 and 0.5% (w/v) concentrations and gellan gum at 0.5% concentration significantly enhanced (P 
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: 25 April 2020Source: Food Chemistry, Volume 310Author(s): Jing Zhao, Zhaorui Meng, Zexin Zhao, Longshan ZhaoAbstractA green and highly efficient ultrasound-assisted deep eutectic solvent extraction combined with functionalized magnetic multi-walled carbon nanotubes solid-phase extraction method for determination of seven pesticide residues in food products was developed. Various types of deep eutectic solvents (DESs) were screened for high extraction efficiencies and DES composing of proline and propylene glycol at 1:3 M ratio was selected as it exhibited highest yields. Extraction conditions were st...
Source: Food Chemistry - Category: Food Science Source Type: research
Authors: Volpini L, Mazza C, Mallia L, Guglielmino N, Rossi Berluti F, Fernandes M, Violani C Abstract Background: Reliable Fertility-specific QoL measures can be obtained through the FertiQoL, a questionnaire with six-subscales that consider different core aspects of the person's wellbeing and way of behaving during treatment.Objective: Examine the psychometric properties of all six-subscales of the Italian FertiQoL in a sample of infertile women and explore the effects of the ART treatment phases.Method: 323 women, in three different treatment stages (Diagnostic, Stimulation, Transfer), completed the FertiQoL. Ra...
Source: Journal of Reproductive and Infant Psychology - Category: Psychiatry & Psychology Tags: J Reprod Infant Psychol Source Type: research
CONCLUSIONS: HVLF and EDS produced a deep intranasal/intrasinal deposition in the silicone cast compared with conventional nasal spray delivery; both deposited liquid inside the surgically opened sinuses. HVLF offers the benefit of lavage, whereas EDS may be more efficient and convenient. PMID: 31813944 [PubMed - as supplied by publisher]
Source: Rhinology - Category: ENT & OMF Tags: Rhinology Source Type: research
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