ATP1A1 Integrates AKT and ERK Signaling via Potential Interaction With Src to Promote Growth and Survival in Glioma Stem Cells

In conclusion, our study demonstrated for the first time that ATP1A1 supports proliferation and survival in primary human GSCs and revealed that Src may be a key molecule involved in ATP1A1-dependent PI3K and MAPK pathway activation. Our findings will aid in further basic research and may provide a novel approach to sabotaging GSCs and glioma therapies based on stemness-related targets. Ethics Statement In this study, all procedures were approved by Ethics Review Board of Chongqing Medical University (Chongqing, China), and gained the written consent of all patients. Author Contributions SW and SC designed and conducted the research, analyzed the data, and critically reviewed the manuscript. YY, CC, and JD performed the experiments, analyzed data, and drafted the original manuscript. GH, HZ, LJ, and RX participated in data analysis. All authors read and approved the final manuscript. Funding This work was supported by the Chongqing Natural Science Foundation Project (No. cstc2016jcyjA0838), the Chongqing Science and Technology Committee, Basic Research and Frontier Exploration (No. cstc2018jcyjA1470), Scientific and Technological Research Program of Chongqing Municipal Education Commission (Grant No.KJ1600201) and Chongqing Yuzhong Science and Technology Commission, Yuzhong Science and technology project (20160112). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research