Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes

Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes Vinay Kumar1, Workineh Torben2, Joshua Mansfield3, Xavier Alvarez3, Curtis Vande Stouwe4, Jian Li5, Siddappa N. Byrareddy6, Peter J. Didier3, Bapi Pahar3, Patricia E. Molina4,7 and Mahesh Mohan3* 1Nektar Therapeutics, South San Francisco, CA, United States 2Department of Biological Sciences, LSU, Alexandria, LA, United States 3Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States 4Department of Physiology, LSUHSC, New Orleans, LA, United States 5Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States 6Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States 7LSUHSC Alcohol and Drug Abuse Center, New Orleans, LA, United States Cannabis use is frequent in HIV-infected individuals for its appetite stimulation and anti-inflammatory effects. To identify the underlying molecular mechanisms associated with these effects, we simultaneously profiled micro-RNA (miRNA) and mRNA expression in the colon of chronically simian immunodeficiency virus (SIV)-infected rhesus macaques administered either vehicle (VEH/SIV; n = 9) or Δ9-tetrahydrocannabinol (Δ9-THC; THC/SIV; n = 8)....
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 14 December 2019Source: Biotechnology ReportsAuthor(s): Seema Mehandia, S.C. Sharma, Shailendra Kumar AryaAbstractA laccase producing new bacterial strain (Alcaligenes faecalis XF1) was isolated from green site of Chandigarh (India) by standard screening method. Nutrient broth medium containing 0.2 mM CuSO4 was used for the production of laccase. Maximum production (110 U/ml) was achieved after four days of incubation. The extracellular laccase from the medium was purified by simple salt precipitation and ion exchange technique to get 3.8 fold purified protein with 1637.8 U/mg spec...
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
This study suggests that these bioformulations could be essential towards sustainable agricultural science deprived of harming the ecosystem. The synthesized bioformulations have enormous potential to be commercially explored for agriculture use.Graphical abstract
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 14 December 2019Source: Journal of Molecular StructureAuthor(s): Katia Le Barbu-Debus, Debora Scuderi, Valeria Lepère, Anne ZehnackerAbstractThe mixed sodium core dimers of dimethyl-l-tartrate (Lmt) and the two enantiomers of diisopropyl tartrate (Lipt and Dipt) are studied by mass spectrometry coupled with laser vibrational spectroscopy. Infra-Red Multiple Photon Dissociation (IRMPD) spectra of the two diastereomer sodium-core dimers, namely, LmtLiptNa+ and LmtDiptNa+, are identical in the fingerprint region but show a slight difference in the OH stretch region. Comparison to ab i...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 15 December 2019Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Shengming Sun, Ying Wu, Ivan Jakovlić, Hongtuo Fu, Xianping Ge, Hui Qiao, Wenyi Zhang, Shubo JinAbstractThe oriental river prawn, Macrobrachium nipponense, is a commercial freshwater prawn species in China. It is highly sensitive to hypoxia, and this has posed a challenge to its intensive culturing. To date, the effects of hypoxia on reproduction in female prawns are not entirely clear, as are the underlying mechanisms of the effects of hypoxia. In this work, comparative t...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 14 December 2019Source: Thermochimica ActaAuthor(s): Vargas H. María Ángeles, Belkis Sulbarán-Rangel, Humberto Vázquez-TorresAbstractThe non-isothermal curing kinetics of furfuryl alcohol (FA) with p-toluenesulfonic acid (p-TSA-2 wt%), two graphene oxides with different content of oxygen and a high thermally reduced graphene oxide at different concentrations (2, 4, 6 wt%) were studied by DSC using four heating rates (5, 7.5, 10 and 15 K min-1). The graphene particles were characterized by infrared spectroscopy, Raman spectroscopy, 13C solid...
Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 15 December 2019Source: European Polymer JournalAuthor(s): Nana Zhang, Shoujuan Wang, Magdi E. Gibril, Fangong KongAbstractApplication of the lignin-based monomer in polymers synthesis will reducing the use of petrochemical-based monomers, enhance the polymer/copolymers properties, and disposing lignin in a profitable way. Accordingly, in this work, the lignin-vinyl acetate monomer (LVAc) and its copolymers were synthesized successfully. To obtain the LVAc, firstly, lignin was activated with the amine using diethylenetriamine (DETA) and then followed by the grafting with chlorovinyl aceta...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 14 December 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Yiye Wang, Xueyan Luo, Ye Han, Baijun Liu, Yiwei Hu, Xiangchi LiuGraphical AbstractSchematic representation of in situ charge neutralization in emulsion polymerization of styrene controlled by pH conditions using AIBA as the initiator.AbstractStyrene emulsion polymerizations using sodium dodecyl sulfate as an anionic surfactant and in the presence of cationic initiators 2, 2′- Azobis (2-methylpropionamidine) dihydrochloride (AIBA) and 2,2′-azobis(N,N′-dimethyleneisobutyrami...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: December 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 12Author(s): Long-Chun BIAN, Cheng-Xiong WANG, Yan-Xiong LIU, Qiu-E CAO, Yun-Kun ZHAOAbstractThe thickness of washcoat loading on high-performance monolithic catalysts is normally determined by vernier caliper procedure, which gives rough result of washcoat thickness but does not address such parameters as morphology and homogeneity, accurate thickness of the layer and chemical composition of the coated layers in honeycomb-shaped monolithic catalysts. In this work, we proposed a methodology of washcoat analysis including the th...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
In this study four kinds of fingerprints, including sweat, inkpad, sunscreen, and liquid foundation, were analyzed by air-flow assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI). AFADESI was employed with air flow of 45 L min−1, and 5 μL min−1 acetonitrile was used as spray solvent at spray voltage of 7000 V. Positive ion full scan mode (100−1000 Da) was chosen. The results showed that AFADESI-MSI method could not only obtain chemical information of various endogenous and exogenous substances in fingerprints, but also obtain high resolution images of fingerprints. In ad...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
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