Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes

Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes Vinay Kumar1, Workineh Torben2, Joshua Mansfield3, Xavier Alvarez3, Curtis Vande Stouwe4, Jian Li5, Siddappa N. Byrareddy6, Peter J. Didier3, Bapi Pahar3, Patricia E. Molina4,7 and Mahesh Mohan3* 1Nektar Therapeutics, South San Francisco, CA, United States 2Department of Biological Sciences, LSU, Alexandria, LA, United States 3Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States 4Department of Physiology, LSUHSC, New Orleans, LA, United States 5Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States 6Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States 7LSUHSC Alcohol and Drug Abuse Center, New Orleans, LA, United States Cannabis use is frequent in HIV-infected individuals for its appetite stimulation and anti-inflammatory effects. To identify the underlying molecular mechanisms associated with these effects, we simultaneously profiled micro-RNA (miRNA) and mRNA expression in the colon of chronically simian immunodeficiency virus (SIV)-infected rhesus macaques administered either vehicle (VEH/SIV; n = 9) or Δ9-tetrahydrocannabinol (Δ9-THC; THC/SIV; n =...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research