Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1

Discussion A preventative strategy aimed at protecting against HIV infection must block several steps during the earliest stages of infection, avoiding not only the productive infection of primary target cells, but also the viral dissemination toward distal tissues. In both scenarios, antigen-presenting cells residing in different compartments of the female genital mucosa may play a prominent role (7, 9, 24, 35). DC-T cell conjugates represent an optimal milieu for productive HIV infection, which may boost initial viral replication of CD4+ T cells (10, 36). Moreover, uninfected DCs could promote HIV dissemination to draining lymph nodes after mucosal challenge (8, 9). Yet, the precise molecular mechanism mediating these processes remained unexplored in the cervicovaginal tissue. Here we have shown the ability of Siglec-1 to mediate viral capture and transmission to target cells on a population of cervical myeloid cells expressing HLA-DR, CD11c, CD14, and CD11b, all classical markers known to be present on DCs of the submucosa at the lower female genital tract (18, 28, 29, 37). Our findings concur with prior studies where the migratory CD3− HLA-DR+ fraction or the cervicovaginal CD11c+ DCs were found to be the myeloid cell subset that preferentially captured and transported HIV-1 out of the cervicovaginal mucosa (5, 16, 17). Nevertheless, we now show that on DCs of the ectocervix and endocervix, alternative receptors beyond DC-SIGN operate in HIV-1 viral uptake and tra...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
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