Bioprospecting of Novel and Bioactive Metabolites from Endophytic Fungi Isolated from Rubber tree Ficus elastica Leaves.

In this study, forty-two endophytic filamentous fungi were isolated from Ficus elastica leaves, and further identified as seven individual taxa by ITS-rDNA sequencing. The antimicrobial activity of these endophytic fungi were evaluated against five pathogenic microorganisms. Two strains Fes1711 (Penicillium funiculosum) and Fes1712 (Trichoderma harzianum) displayed broad-spectrum bioactivities. Our following study emphasized on the isolation, identification and bioactivity test of chemical metabolites produced by T. harzianum Fes1712. Two new isocoumarin derivatives (1 and 2), together with three known compounds (3-5) were isolated, and their structures were elucidated using NMR and MS. Compounds 1 and 2 exhibited inhibitory activity against E. coli. Our findings reveal that endophytic fungi from the rubber tree F. elastica leaves exhibit unique characteristics and are potential producers of novel natural bioactive products. PMID: 31030449 [PubMed - as supplied by publisher]
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research