Role of DNA Methylation Profile in Diagnosing Astroblastoma: A Case Report and Literature Review

Conclusion Astroblastoma is an extremely rare CNS tumor. Morphological diagnosis is difficult, as the typical astroblastic rosettes may be present also in other CNS tumors, including some gliomas and ependymomas. In fact, AB can be considered as a morphologic pattern, which can be associated with a spectrum of molecular entities. Total resection is the best treatment; the precise role of chemotherapy and radiotherapy is still debated, particularly for high-grade tumors. We believe that DNA-methylation profiles represents an important instrument for confirming diagnosis, predicting prognosis and better defining the molecular characteristics of AB. Ethics Statement This study was carried out in accordance with the recommendations of the Internal Review Board of the Bambino Gesù Ospedale Pediatrico with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Internal Review Board of the Bambino Gesù Ospedale Pediatrico. Author Contributions GP designed the work, structured the study, interpreted the data, and wrote the manuscript. IA acquired the data, and structured and revised the manuscript. GC acquired and elaborated the images. FD-C performed the pathological findings. ACi performed the bioinformatics analysis. LP acquired the data. ACa contributed to patient management and revision. ACar contributed to neurosurgery and revision. MT supervised...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
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Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
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Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
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Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
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