Trends in Surgical Management of Multicystic Dysplastic Kidney at U.S. Children ’s Hospitals

and Objective: Multicystic dysplastic kidney (MCDK) is a congenital renal cystic disease often incidentally diagnosed in children. Historically, children with MCDK underwent early nephrectomy due to concerns for the development of hypertension or malignancy. Over the last decade, management recommendations have not supported routine early surgical removal of MCDK. We sought to determine the current trends in the use of nephrectomy for MCDK in US children ’s hospitals, as national practice patterns have not been investigated.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research

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Rationale: Conventional computerized tomography (CT) examination can differentiate renal cortical tumor from urothelial carcinoma on the basis of the highly contrast-enhanced vessels in renal cortical tumors. However, the capillary distribution of renal cell carcinoma (RCC) has been under-investigated. Here, we present a micro-CT image of tumor tissue in a patient with RCC. Patient concerns: The patient was a 72-year-old woman with a past history of diabetes mellitus and hypertension. She did not have tumor-related symptoms. Diagnosis and interventions: The tumor was diagnosed using abdominal CT during her yearly r...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
CK, Zatz R Abstract Hypoxia is thought to influence the pathogenesis of chronic kidney disease (CKD), but direct evidence that prolonged exposure to tissue hypoxia initiates or aggravates CKD is lacking. We tested this hypothesis by chronically exposing normal rats and rats with 5/6 nephrectomy (Nx) to hypoxia. In addition, we investigated whether such effect of hypoxia would involve activation of innate immunity. Adult male Munich-Wistar rats underwent Nx (n=54) or sham surgery (S, n=52). Twenty six sham (S+Nor) and 26 Nx (Nx+Nor) rats remained in normoxia, while 26 sham rats (S+Hyp) and 28 Nx rats (Nx+Hyp) were ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
ConclusionTransplantation from living donors allows better results in terms of graft survival without exposing the donor to inconsiderate risks, provided that the donors are properly selected.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
A 55-year-old man with a history of end-stage renal disease due to autosomal dominant polycystic kidney disease and bilateral nephrectomy without adrenalectomy underwent his first kidney transplantation after 6 years of hemodialysis. The patient had no history of donor-specific antibodies. The donor was described as a 69-year-old man with a history of active smoking and  aortic valvulopathy who died of a stroke without cardiac arrest or collapse. Maintenance immunosuppressive therapy consisted of low-dose tacrolimus and everolimus.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Raj K Yadav, Dipankar Bhowmik, Arunkumar Subbiah, Sushma Yadav, Soumita Bagchi, Sandeep Mahajan, Sanjay K AgarwalIndian Journal of Nephrology 2019 29(4):272-277 Prospective living kidney donors need meticulous evaluation prior to kidney donation. Ambulatory blood pressure monitoring (ABPM) is considered the reference standard for diagnosing hypertension. With no prior study available in India in this context, we undertook this study to evaluate the utility of ABPM in kidney donors and effect of donor nephrectomy on renal function. This was a prospective observational study involving healthy prospective kidney donors betwe...
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
α-calcitonin gene related peptide (α-CGRP) is a regulatory neuropeptide of 37-amino acids. It is widely distributed in the central and peripheral nervous system, predominantly in cell bodies of the dorsal root ganglion (DRG). It is the most potent vasodilator known to date and has ionotropic and chronotropic effects. Using pharmacological and genetic approaches our laboratory and other research groups established the protective role of α-CGRP in various cardiovascular diseases such as heart failure, experimental hypertension, myocardial infarction, and myocardial ischemia/reperfusion injury (I/R injury). ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract Living donor kidney transplantation is the treatment of choice for the patients with end-stage renal disease, especially where deceased donor programs are limited. There are limited data on the outcomes of living kidney donors (LKD) from developing countries, especially from North Africa. The aim of this study is to evaluate the prevalence of hypertension (HTN) in LKD and to analyze its risk factors. This is a longitudinal monocentric study, and the donors who underwent nephrectomy for donation between 2006 and 2015 were included. Ninety-two donors were assessed. The mean age at the time of nephrectomy wa...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
Secondary hypertension due to a poorly functioning or nonfunctional kidney may be refractory to medical management. In such cases nephrectomy can improve or cure hypertension. With the routine use of laparoscopy, nephrectomy can be performed in a minimally invasive manner, but surgery still carries inherent risks and complications.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research
Conclusions. In this national study, new-onset diabetes was rare, but 3% of donors developed hypertension within 2 years of nephrectomy. These findings reaffirm that disease pathways for kidney failure differ by donor phenotype and estimate the population most at-risk for later kidney failure.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
We report on the case of a partial nephrectomy for a Juxtaglomerular apparatus (JGA) tumour in a 28 year old female who presented with fatigue and symptomatic hypertension, and a normal serum renin level on pre-operative work-up.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
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