Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats
Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats Sandip T. Auti and Yogesh A. Kulkarni* Shobhaben Pratapbhai Patel School of Pharmacy &Technology Management, SVKM's NMIMS, Mumbai, India Acetylcholinesterase (AChE) is an enzyme involved in the progression of Alzheimer's disease (AD). Cardamom oil (CO) has been reported to have acetylcholinesterase inhibitory, antioxidant and anti-anxiety effects. Hence, we studied the effect of cardamom oil in aluminum chloride induced neurotoxicity in rats. AD like symptoms were induced in Wistar rats with aluminum chloride (100 mg/kg, p.o.). Cardamom oil was administered concomitantly by oral route at doses of 100 and 200 mg/kg for 42 days. Behavioral parameters like Morris water maze, elevated plus maze, passive avoidance test and locomotor activity were evaluated on day 21 and 42. AChE activity, oxidative stress parameters, histopathological studies and immunohistochemistry studies were carried out in hippocampus and cortex. Cardamom oil treatment showed significant improvement in behavioral parameters, inhibition of AChE activity (p
Soft Matter, 2020, Accepted Manuscript DOI: 10.1039/D0SM00929F, PaperOlena V. Goncharuk, Yurii M. Samchenko, Liudmyla O. Kernosenko , Olena I. Korotych, Tetiana P. Poltoratska, Natalia O. Pasmurtseva, Olena Oranska, Dariusz Sternik, Igor Mamyshev Recently, considering the potential applications of hydrogel nanocomposites in biomedical engineering, there has been a growing interest in the synthesis of hydrogels with improved mechanical properties. Among magnetic materials, iron... The content of this RSS Feed (c) The Royal Society of Chemistry
Publication date: Available online 31 May 2020Source: Journal of Hazardous MaterialsAuthor(s): Nicolás Arancibia-Miranda, Karen Manquián-Cerda, Carmen Pizarro, Tamara Maldonado, Jonathan Suazo-Hernández, Mauricio Escudey, Nanthi Bolan, Binoy Sarkar
Publication date: Available online 31 May 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Badmus O. Olufunto, Njan Anoka, Ologe M. Olufunmilayo, Olatunji A. Lawrence
His group will study how abnormal calcium signals may contribute to human diseases such as allergies and asthma. (read more)
[WHO] Geneva/Brazzaville/Kinshasa -The Government of the Democratic Republic of the Congo (DRC) announced today that a new outbreak of Ebola virus disease is occurring in Wangata health zone, Mbandaka, in Équateur province. The announcement comes as a long, difficult and complex Ebola outbreak in eastern DRC is in its final phase, while the country also battles COVID-19 and the world's largest measles outbreak.
[RFI] Five new cases of Ebola have been declared in the north-western region of the Democratic Republic of Congo, according to Health Minister Eteni Longondo, who said four of the five cases had already died.
BACKGROUND: Research suggests that acute alcohol consumption impairs processing of emotional faces. As emotion processing plays a key role in effective social interaction, these impairments may be one mechanism by which alcohol changes social behaviour. Th...
BACKGROUND: The United States (US) and Canada are in the midst of an opioid overdose epidemic. Many people who use illicit drugs (PWUD) do not call an emergency number 911 at the scene of an overdose due to fear of arrest. In the US and Canada, when an ind...
OBJECTIVES: Women have a higher incidence of mental health problems compared with men. Psychosocial stressors at work are associated with mental health problems. However, few prospective studies have examined the association between these stressors and obj...
BACKGROUND Intra-abdominal impalement injuries caused by a penetrating foreign body are rare and often fatal. The mechanism of injury is usually associated with vascular and organ damage, and the course is dynamic, with high morbidity and mortality. Post-t...
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