Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats

Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats Sandip T. Auti and Yogesh A. Kulkarni* Shobhaben Pratapbhai Patel School of Pharmacy &Technology Management, SVKM's NMIMS, Mumbai, India Acetylcholinesterase (AChE) is an enzyme involved in the progression of Alzheimer's disease (AD). Cardamom oil (CO) has been reported to have acetylcholinesterase inhibitory, antioxidant and anti-anxiety effects. Hence, we studied the effect of cardamom oil in aluminum chloride induced neurotoxicity in rats. AD like symptoms were induced in Wistar rats with aluminum chloride (100 mg/kg, p.o.). Cardamom oil was administered concomitantly by oral route at doses of 100 and 200 mg/kg for 42 days. Behavioral parameters like Morris water maze, elevated plus maze, passive avoidance test and locomotor activity were evaluated on day 21 and 42. AChE activity, oxidative stress parameters, histopathological studies and immunohistochemistry studies were carried out in hippocampus and cortex. Cardamom oil treatment showed significant improvement in behavioral parameters, inhibition of AChE activity (p
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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