Control of MHC II antigen presentation by ubiquitination.

Control of MHC II antigen presentation by ubiquitination.
Curr Opin Immunol. 2012 Nov 23;
Authors: Moffat JM, Mintern JD, Villadangos JA
Abstract
MHC II antigen presentation is a critical pathway involved in the activation of the adaptive immune system. Tight regulatory controls are necessary to ensure appropriate MHC II antigen presentation. One mechanism for regulating this pathway is ubiquitination. Ubiquitination has been shown to play a critical role in fine-tuning the regulation of MHC II antigen presentation, with significant roles in antigen receptor internalisation and turnover of MHC II at the cell surface. The importance of ubiquitination is highlighted by bacterial pathogens that hijack the pathway to evade immune recognition. Understanding how ubiquitin E2 and E3 ligases contribute to controlling MHC II antigen presentation will shed light on the critical regulatory controls of this important pathway of immunity.
PMID: 23183035 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - November 23, 2012 Category: Allergy & Immunology Authors: Moffat JM, Mintern JD, Villadangos JA Tags: Curr Opin Immunol Source Type: research