Antigen presentation by Langerhans cells.

Antigen presentation by Langerhans cells.
Curr Opin Immunol. 2012 Dec 12;
Authors: Igyártó BZ, Kaplan DH
Abstract
Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response. This review focuses on the functional outcome of antigen presentation by Langerhans cells. Special attention is given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts and whether this subset has the capacity to cross-prime CD8 T cells.
PMID: 23246038 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - December 12, 2012 Category: Allergy & Immunology Authors: Igyártó BZ, Kaplan DH Tags: Curr Opin Immunol Source Type: research