Mass cytometry reveals an impairment of B cell homeostasis in anti-synthetase syndrome

Recent data suggest the implication of T, B and NK cells in the anti-synthetase syndrome (ASyS); nevertheless their role and activation states are poorly described.We performed deep immune-profiling using 37 markers on peripheral blood cells from 10 ASyS patients versus 17 healthy donors (HD) and 26 myositis control patients.We show decreased percentages of memory B cells in ASyS patients (mean  ± SEM: ASyS = 13 ± 3%, HD = 37 ± 4% and ‘myositis controls’ = 32 ± 3), counterbalanced by increased percentages of naïve B cells.

Source: Journal of Neuroimmunology - April 28, 2019 Category: Allergy & Immunology Authors: Ga ëlle Dzangué-Tchoupou, Yves Allenbach, Corinna Preuße, Werner Stenzel, Olivier Benveniste Tags: Short Communication Source Type: research