Immunomodulatory Effects of Breast Milk on Food Allergy

Human milk (HM) is not only considered the ideal nutrition source for term infants during the first six months of life by providing nutrients needed for growth and development 1, but it also provides antimicrobial and immunomodulatory factors providing defense against infections 2, 3. Thereby, breastfeeding provides continued exposure to the mother ’s immune system during the crucial window of first few months of life, when the infant’s immune system is constantly developing. However, the immunomodulatory make up of HM has not been well-characterized and demonstrates a great deal of variability between mothers, which implies that the benef it of breastfeeding to the breastfed infants may differ between dyads.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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By Mahboobeh Mahdavinia Alanna and Anthony are not yet ten years old, but they have been to the emergency room more times than most adults. Every few months since they were babies, their parents have raced them to the hospital for asthma attacks, superinfections of their severe eczema, or food allergy reactions. They each have […]
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Uncategorized Source Type: blogs
For this ‘From the Pages of Allergy Watch’ reviews from several recent issues were selected which review articles about Allergic Skin Diseases, the focus of this issue of the Annals. The first article describes a unique minimally invasive method of skin tape stripping to identify infants with atopic derm atitis who are at increased risk for food allergy. The next study investigates the difference between IgE sensitivity and clinical reactivity to foods in children with atopic dermatitis. The last investigates the impact of UV light exposure and the development of atopic dermatitis in infancy.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Recent epidemiological studies suggest that non-IgE-mediated childhood food allergic disorders such as eosinophilic esophagitis (EOE), celiac disease and allergic gastroenteritis (AG), may be increasing in parallel with previously observed increases in childhood IgE-mediated food allergy (FA) and food-induced anaphylaxis (FIA)1-4. The term AG encompasses food protein induced enterocolitis syndrome (FPIES), eosinophilic enteritis and colitis, food protein induced enteropathy, food hypersensitivity enteritis and colitis, but not EOE.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
i Asthma is a chronic respiratory disease which is associated with higher levels of systemic inflammation. The causes of asthma remain poorly understood. Unhealthy diet and food allergy are potential risk factors for developing asthma. The prevalence of asthma in the Arabian Gulf region (AGR), and Kuwait, Saudi Arabia and Qatar in particular, is higher than in other Eastern Mediterranean countries. In the AGR, diets tend to be of low nutritional value due to high levels of total energy, cholesterol, sodium, added sugars and saturated fat, and low levels of fiber, fruit and vegetables. A few studies that include childre...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Commentary Source Type: research
In this study we observed an association between allergic disease and communication skills development as assessed by the Ages and Stages Questionnaire (ASQ) communication score, as a proxy for ASD, among children who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In particular, we observed significant associations between both a diagnosis of eczema at age 3 years (OR=1.87; confidence interval [CI]: 0.97-3.47; p=0.054) and a diagnosis of food allergy at age 6 years (OR=3.61; 95% CI: 1.18-9.85; p=0.015) with ASQ communication score. Plasma metabolomics analyses suggest that dysregulated tryptophan ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
In this study we observed an association between allergic disease and communication skills development as assessed by the Ages and Stages Questionnaire (ASQ) communication score, as a proxy for ASD, among children who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In particular, we observed significant associations between both a diagnosis of eczema at age 3 years (OR=1.87; confidence interval [CI]: 0.97-3.47; p=0.054) and a diagnosis of food allergy at age 6 years (OR=3.61; 95% CI: 1.18-9.85; p=0.015) with ASQ communication score. Plasma metabolomics analyses suggest that dysregulated tryptophan ...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Conclusions: Our study confirms that CD and PWAG share comorbidities of autoimmune nature. PWAG had more autoimmune/allergy-related disorders that may be associated with non-celiac gluten sensitivity a self-justifiable reason to be on the diet.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research
In this study, we investigated the clinical manifestations and risk factors for anaphylaxis in PFAS in Korean patients with pollinosis. MATERIALS AND METHODS: Data were obtained from a nationwide cross-sectional study that previously reported on PFAS in Korean patients with pollinosis. Data from 273 patients with PFAS were collected, including demographics, list of culprit fruits and vegetables, and clinical manifestations of food allergy. We analyzed 27 anaphylaxis patients and compared them with patients with PFAS with oropharyngeal symptoms only (n=130). RESULTS: The most common cause of anaphylaxis in PFAS wa...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Non-specific lipid transfer proteins (nsLTPs) are a group of highly conserved, low-molecular-weight proteins that are found throughout the plant kingdom 1. nsLTPs are believed to have an important role in plant defence 2 and are concentrated in the skin of many fruits including those belonging to the Rosaceae family 1,3, of which the peach and it ’s nsLTP Pru p 3 is the most well characterised 1. nsLTP allergy is a common type of food allergy in the Mediterranean, but it is thought to be uncommon in Northern and Central Europe 4.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Associations between allergic disease and puberty amongst females have been widely studied. However, this association has received less attention in multigenerational populations. To this end, we sought to exa...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the editor Source Type: research
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