Effects of Remote Ischemic Preconditioning in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
Conclusion: RIPC by upper limb ischemia shortens mechanical ventilation time in patients undergoing OPCABG. RIPC treatment reduces postoperative myocardial enzyme expression and pro-inflammatory cytokine production. RIPC is a protective therapeutic approach in the coronary artery bypass graft surgery.
Introduction
With the change of lifestyle and eating habits, the incidence of coronary artery disease (CAD) in China increased gradually (reported by Xue and Xu, 2017). Those who with multiple CAD need surgery. Off-pump coronary artery bypass graft (OPCABG) is the preferred surgical procedure. Even so, myocardial ischemia-reperfusion injury often occurs after OPCABG and this can not be avoided completely (Chowdhury et al., 2008). Thus, great efforts should be made to alleviate myocardial injury. Remote ischemic preconditioning (RIPC), a non-invasive and operable intervention in the clinic, has drawn the attention of clinicians in recent years.
The phenomenon of RIPC was first reported by Przyklenk et al. (1993) in the end of last century. After several years, the paradigm of “cardioprotection at a distance” by ischemic conditioning was quickly extended to other tissues and organs and to longer distances from the heart (Heusch, 2018). The underlying mechanisms probably include a release of transferable humoral from the perfused tissue and neuronal reflexes (Heusch et al., 2015).
It has been reported that RIPC could be a potential protective approach for pe...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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