An occupational exposure limit (OEL) approach to protect home healthcare workers exposed to common nebulized drugs
Publication date: Available online 29 April 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Evan Frank, Simileoluwa Ishau, Andrew Maier, Susan Reutman, John F. ReichardAbstractHome healthcare is a growing area of employment. Assessment of occupational health risks to home health care workers (HHCWs) is important because in many cases the unique characteristics of the home environment do not facilitate the level of exposure control afforded to caregivers in hospitals and other fixed patient care sites. This assessment is focused on health risks to HHCWs from exposure to pharmaceutical drugs used to treat asthma and other respiratory diseases, which are commonly administered to patients in aerosolized form via nebulizers. We developed risk-based exposure limits for workers in the form of occupational exposure limits (OEL) values for exposure to nebulized forms of three drugs most commonly administered by this method: albuterol, ipratropium, and budesonide. The derived OEL for albuterol was 2 μg/day, for ipratropium was 30 μg/day, and for budesonide was 8 μg/day. These OELs were derived based on human effect data and adjusted for pharmacokinetic variability and areas of uncertainty relevant to the underlying data (human and non-human) available for each drug. The resulting OEL values provide an input to the occupational risk assessment process to allow for comparisons to HHCW exposure that will guide risk management and exposure control decisions.
Conclusions: Collectively, these findings suggest that although NiO surface area correlates best with acute pulmonary injury and inflammation following respiratory exposure, other physico-chemical properties may contribute to the modulation of immune responses in the lung. PMID: 31707870 [PubMed - as supplied by publisher]
Exhaled TGF-β1 levels before and after an exercise challenge in asthmatic and healthy children, and during exacerbation. J Asthma. 2019 Nov 11;:1-10 Authors: Keskin O, Ozkars MY, Gogebakan B, Kucukosmanoglu E, Keskin M, Bayram H Abstract Background: There is conflicting data regarding the role of transforming growth factor-β1 (TGF-β1) in the pathogenesis of airway hyper-reactivity and asthma exacerbation.Objective: To investigate the role of exhaled-TGF-β1 in exercise-induced bronchospasm (EIB) in asthmatic and nonasthmatic healthy children, and in asthma exacerbation and asthma con...
Condition: Mild or Moderate Asthma With Allergic Sensitization Interventions: Drug: 5-Hydroxytryptophan; Drug: Placebo Sponsor: Indiana University Active, not recruiting
Condition: Asthma; Allergic Rhinitis Interventions: Drug: CSPCHA115 100 mg; Matching placebo 100 mg; Drug: CSPCHA115 200 mg; Matching placebo 200 mg; Drug: CSPCHA115 400 mg; Matching placebo 400 mg; Drug: CSPCHA115 600 mg; Matching placebo 600 mg Sponsor: CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Not yet recruiting
ConclusionsPercent-predicted FEV1 and FVC values for normal children with a T1–T12 height of 22 cm at skeletal maturity were
Research shows that dietary changes can help to manage conditions such as diabetes and asthma, so undergraduate pharmacy courses must better prepare pharmacists to advise patients on healthy eating behaviours.
AbstractCurcumin, extracted from the roots ofCurcuma longa, has been used as an anti-inflammatory agent since the time of Ayurveda. The present work was designed to evaluate the potential of curcumin in amelioration of ovalbumin (OVA) induced AD in mice. Female BALB/c mice were subjected to skin OVA-patch application for a period of 1 week followed by resting period of 2 weeks, and the same protocol was repeated thrice. Curcumin was administered daily at dose of 20 mg/kg (i.p.) for 7 consecutive days during last sensitization phase. The phytochemical ameliorated the OVA-induced skin pathology as evident by normalization of...
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inapaw Teatske Altenburg For children with asthma, physical activity (PA) can decrease the impact of their asthma. Thus far, effective PA promoting interventions for this group are lacking. To develop an intervention, the current study aimed to identify perspectives on physical activity of children with asthma, their parents, and healthcare providers. Children with asthma between 8 and 12 years old (n = 25), their parents (n = 17), and healthcare providers (n = 21) participated in a concept mapping study. Participants generated ideas that would help children with asthma to become more physically active. They sorted a...