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Paediatricians for a Healthy Environment

A group of Argentine paediatricians has been combining work on environmental protection and child health for more than 10 years. It appears a basic principle to apply, but the task is turning out to be increasingly challenging and complex. “We can’t clean up a river, or give a family a new house, but we can teach people to put chlorine in the water,” Dr. Stella Maris Gil, the coordinator of the Environmental Paediatric Unit (UPA) at the Pedro de Elizalde Children’s Hospital in the Constitución neighbourhood of Buenos Aires, told IPS. The UPA provides health care with a strong environmental component, educates the public using the hospital, trains doctors and carries out research, explained Gil and other paediatricians belonging to the unit. “The idea arose in the 2001 crisis,” Gil said, referring to the economic and social collapse at the end of that year, when poverty and unemployment reached unprecedented levels in Argentina and also had an impact on health. “We were seeing a lot of illness connected to poor living conditions: respiratory diseases, gastroenteritis, skin infections … So we decided to give courses on the impact of environmental pollution on health, and we devised a project aimed at protecting the environment in order to provide better health care for children,” she said. The project, which gave rise to the UPA, had a healthcare component “with strong environmental awareness,” Gil said, ...
Source: IPS Inter Press Service - Health - Category: Global & Universal Authors: Tags: Active Citizens Civil Society Development & Aid Environment Featured Headlines Health Human Rights Latin America & the Caribbean Poverty & MDGs Regional Categories Women's Health Argentina Maternal and Child Health Pollution Source Type: news

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This report is describing the case of a patient who developed parallel two different mechanisms of resistance: A T790 M resistance mutation and a transformation into a small cell neuroendocrine cancer. Under therapy with Osimertinib and chemotherapy with carboplatin and etoposide the tumor responsed partially. PMID: 29466812 [PubMed - as supplied by publisher]
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
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Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Tags: Am J Health Syst Pharm Source Type: research
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Source: Herz - Category: Cardiology Tags: Herz Source Type: research
The objective was to test the in vitro activities of ceftaroline and comparator agents against clinical isolates of Gram-negative and Gram-positive bacteria. Isolates were identified with VITEK II. Susceptibility testing was with E test. A total of 1264 isolates were tested. Compared to other cephalosporins, ceftaroline demonstrated excellent in vitro activities (MIC90, ≤0.5 mg/L) against Escherichia coli, Salmonella spp. and Haemophilus influenzae. When matched with the comparator cephalosporins, ceftaroline demonstrated the greatest activity against methicillin-susceptible Staphylococcus aureus (MSSA), with MIC90...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
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Source: Acta Neurologica Taiwanica - Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Authors: Sun H, Hu P, Du J, Wang X Abstract Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresectable lung cancer that were treated with first-line chemotherapy between January 2007 and December 2011 were retrospectively identified, and chemotherapeutic response was evaluated following 2 or 3 chemotherapy cycles. Prior to chemotherapy, hematologic data a...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: He XJ, Bian EB, Ma CC, Wang C, Wang HL, Zhao B Abstract The long non-coding RNA SPRY4-intronic transcript 1 (SPRY4-IT1) has been shown to promote the progression of cancer; however, the role of SPRY4-IT1 in glioma remains unclear. The present study demonstrated that SPRY4-IT1 expression was markedly increased in glioma tissues and cells compared with normal brain tissues, whereas knockdown of SPRY4-IT1 inhibited cell proliferation, migration, and invasion in U251 cells. Spindle and kinetochore associated complex subunit 2 (SKA2) was found to be a target of SPRY4-IT1 and was downregulated by SPRY4-IT1-knock...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Zhou R, Huang Y, Cheng B, Wang Y, Xiong B Abstract Type 1 transforming growth factor β receptor (TGFBR1)*6A, a common hypomorphic variant of TGFBR1, may act as a susceptibility allele in colorectal cancer. However, the contribution of TGFBR1*6A to colorectal cancer development is largely unknown. To test the hypothesis that TGFBR1*6A promotes colorectal cancer invasion and metastasis via Smad-independent transforming growth factor-β (TGF-β) signaling, the effect of TGFBR1*6A on the invasion of colorectal cancer cells was assessed. pCMV5-TGFBR1*6A-HA plasmids were transfected into SW48 and DL...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Zhang X, Chen Y, Dong L, Shi B Abstract The occurrence of resistance to mitomycin C (MMC) often limits its clinical effectiveness. Combination therapy thus is employed to overcome this treatment resistance. The present study aimed to establish a novel J82 bladder cancer cell line so as to study the effect of inhibition of aquaporin 1 (AQP-1) on chemotherapy sensitivity of J82 bladder cancer cells. A novel J82 bladder cancer cell line whose expression of AQP-1 is inhibited was established through transfection of J82 cells with newly constructed recombinant plasmid. The resulting cell line was designated J82...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Liu F, Pan Z, Zhang J, Ni J, Wang C, Wang Z, Gu F, Dong W, Zhou W, Liu H Abstract Aberrant expression of Ras homolog enriched in brain (RHEB) has been observed in a variety of cancer tissues and is closely associated with clinicopathological features. However, the expression profile of RHEB in patients with hepatocellular carcinoma (HCC) and its clinical signature with underlying mechanisms have not been explored thus far. To analyze the association between RHEB expression and clinicopathological features, the RHEB expression levels were determined in the present study using gene microarrays, immunohistoch...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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