The ubiquitin–proteasome system in kidney physiology and disease

The ubiquitin–proteasome system in kidney physiology and diseaseThe ubiquitin–proteasome system in kidney physiology and disease, Published online: 29 April 2019; doi:10.1038/s41581-019-0148-1The ubiquitin–proteasome system (UPS) maintains protein homeostasis through the selective degradation of proteins. In addition to degrading short-lived and misfolded proteins, the UPS regulates a multitude of cellular processes, including gene transcription and translation, cell survival and metabolism, and inflammation. This Review provides an overview of UPS-mediated proteostasis, focusing on the involvement of the UPS in renal physiology and pathophysiology.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research