Persisting enteropathy and disturbed adaptive mucosal immunity due to MHC class II deficiency.

We describe multifaceted disturbance of adaptive mucosal immunity in MHC II deficient patients suffering from enteropathy. HLA-DR and Ii expression on enterocytes is not restored by HSCT. This may account for increased susceptibility to enteric infections and intestinal inflammation leading to prolonged enteropathy reported in MHC II deficient patients.
PMID: 31028919 [PubMed - as supplied by publisher]

Source: Clinical Immunology - April 23, 2019 Category: Allergy & Immunology Authors: Posovszky C, Sirin M, Jacobsen E, Lorenz M, Schwarz K, Schmidt-Choudhury A, Rothoeft T, Schuetz C, Hönig M, Debatin KM, Schulz A, Möller P, Barth TF Tags: Clin Immunol Source Type: research