29.04.19: Not intended for U.S. and UK Media

Study reaffirms safety and efficacy profile of Xarelto™ for the prevention of stroke in patients with atrial fibrillationFirst results from RELOADED, an observational study in the EU, indicate that non-vitamin-K oral anticoagulants (NOACs) like Xarelto provide a benefit in renal preservation over time when compared to the vitamin-K antagonist (VKA) phenprocoumon / The data from the comparative effectiveness study in Germany confirm an improved safety outcome and comparable effectiveness for Xarelto compared with phenprocoumon in patients with non-valvular atrial fibrillation (NVAF), including those with renal insufficiency(1)mehr ...
Source: Bayer IR Newsfeed: Events - Category: Pharmaceuticals Source Type: news

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Conditions:   Stroke;   Atrial Fibrillation Intervention:   Device: Smartphone ECG Sponsors:   Sarawak Heart Centre;   Ministry of Health, Malaysia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Objective: To assess the prognostic value of electrocardiographic atrial fibrillation in older hypertensive people in the randomized, placebo-controlled Hypertension in the Very Elderly Trial. Methods: Hypertension in the Very Elderly Trial randomized 3845 hypertensive people aged 80 years and over, 3273 with electrographic data on the presence or absence of atrial fibrillation at baseline and without established cardiovascular disease. Multivariate Cox proportional hazard models were used to estimate hazard ratios with 95% confidence intervals (CIs) for all-cause mortality, incident fatal and nonfatal major cardiovas...
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Risk factors Source Type: research
Oral anticoagulants are prescribed for stroke prophylaxis in patients with atrial fibrillation, which is the most common heart arrhythmia worldwide. The vitamin K antagonist (VKA) warfarin is a long-establishe...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
Authors: Bazarbashi N, Miller M Abstract INTRODUCTION: Icosapent Ethyl (IPE) is a highly purified (>96%) form of eicosapentanoic acid, a marine-derived omega-3 fatty acid known to reduce serum triglyceride levels. Experimental and human studies also support anti-atherosclerotic properties of IPE including antioxidant, anti-inflammatory, endothelial and plaque stabilizing effects. In the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT)l),the addition of 4 grams IPE daily resulted in a 25% reduction in cardiovascular events beyond statins and other standard of care therapies. ...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
Abstract BACKGROUND: Pulmonary vein isolation has become one of core modalities of rhythm control strategy in patients with atrial fibrillation (AF). AIMS: The aim of the study was to analyse temporal trends in availability and efficacy of AF/atrial flutter catheter (AFl) ablation in urban area of Upper Silesia in Poland. METHODS: The source data was obtained from SILCARD database covering an adult population of 3.8 million. The final study population comprised patients referred for catheter ablation with I48 diagnosis code between 2006 and 2017. The data included total number of procedures, patients' se...
Source: Kardiologia Polska - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
This article provides an update on the epidemiology and prevention of a first stroke. Risk factor modification plays a large role in stroke prevention. Strategies for early intervention, particularly for hypertension, are critical for reducing stroke morbidity and mortality. RECENT FINDINGS Because of the new criteria for hypertension, more people are now classified as hypertensive and can benefit from lifestyle or medical management. Direct oral anticoagulants have made it easier to safely treat patients with atrial fibrillation and are now considered first-line therapy for patients with an additional stroke risk facto...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
This article discusses cryptogenic stroke and the results of recent randomized trials that can inform its evaluation and management. RECENT FINDINGS Most cryptogenic strokes appear embolic, leading to the term embolic stroke of undetermined source. It was previously thought that embolic stroke of undetermined source was a single, therapeutically relevant entity, the underlying sources of which would respond to anticoagulant therapy; however, two large randomized trials found no benefit with anticoagulation compared to antiplatelet therapy for secondary stroke prevention after embolic stroke of undetermined source. A sin...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
This article reviews sex differences in stroke risk and presentation, with a particular emphasis on the unique risk factors women experience throughout the lifespan. RECENT FINDINGS Although prior studies suggested women have worse outcomes after stroke, it is now clear that age, prestroke functional status, and comorbidities explain many of the differences between men and women in stroke severity, functional outcomes, and mortality. Several meta-analyses and large cohort studies have evaluated the risk factors for women related to reproductive factors and found that fewer years between menarche and menopause, pregnancy...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
This article reviews the evidence base and recommendations for medical management for secondary stroke prevention. RECENT FINDINGS Recent developments for secondary stroke prevention include evidence to support the use of short-term dual antiplatelet therapy after minor stroke and transient ischemic attack, direct oral anticoagulants for nonvalvular atrial fibrillation, reversal agents for direct oral anticoagulant–associated hemorrhage, and aspirin rather than presumptive anticoagulation with a direct oral anticoagulant for embolic stroke of undetermined source. SUMMARY Most strokes are preventable. The mainst...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
We report a case with uncommon late complication of this device causing erosion of the left ventricle, which open heart operation was carried out to repair the defect.
Source: Surgical Practice - Category: Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
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