Disseminated histoplasmosis in a Brazilian domestic cat: early diagnosis and successful treatment

AbstractHistoplasmosis is a worldwide distributed opportunistic mycosis caused by the dimorphic fungusHistoplasma capsulatum. It is reported in cats with non-specific clinical signs. The aim of this case report is to describe the first case of disseminated histoplasmosis in a cat in the city of Santa Maria, Rio Grande do Sul, Brazil. In veterinary consultation, it was reported that the animal had a history of vomiting, hematochezia, and weight loss for 3  months. At physical exam, an abdominal lymph adenomegaly, an intestine diffusely enlarged, and a poor body condition were observed. Ultrasound-guided fine-needle aspiration cytology (FNAC) of the caudal mesenteric lymph node was performed. Cytology revealed pyogranulomatous infiltrate with the pre sence of yeast organisms, cells compatible withH. capsulatum. The treatment prescribed was itraconazole. Culture of the caudal mesenteric lymph node sample confirmed the cytological diagnosis. Physical, hematological, and ultrasonographic exams were undertaken periodically. On day 139 of treatment, the itraconazole dose was increased once the patient had anemia and periodic vomiting; also, the abdominal lymph node size decrease was not remarkable. After that, the cat showed a better clinical response. On day 459 of treatment, the owners had decided to interrupt the treatment but the cat was still referred to the hospital for clinical and ultrasound evaluation. Fifteen months post diagnosis, the patient was alive and healthy. F...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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ConclusionFour patients were noted to have bone marrow elements on the smears among 63,361 thyroid FNA samples. These four Taiwanese women presented with nodular goiter and foci of hematopoietic elements by thyroid FNA without any chronic disease of hematopoietic tissue or any evidence of a thyroid malignancy.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Authors: Kojić Katović S, Vasilj A, Rinčić G Abstract T-cell large granular lymphocytic leukemia (T-LGLL) is an uncommon but probably underdiagnosed disease caused by clonal proliferation of large granular lymphocytes. Diagnosis is typically based on the high number of morphologically characteristic lymphoid cells and finding of an abnormal immunophenotype by flow cytometry. Because of its relatively indolent clinical behavior, observation is often an appropriate therapy. Here we present a case of a 53-year-old male admitted to the hospital because of abdominal pain. Blood examination revealed mild mycrocitic a...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Conclusion Four patients were noted to have bone marrow elements on the smears among 63,361 thyroid FNA samples. These four Taiwanese women presented with nodular goiter and foci of hematopoietic elements by thyroid FNA without any chronic disease of hematopoietic tissue or any evidence of a thyroid malignancy.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
CONCLUSION: Four patients were noted to have bone marrow elements on the smears among 63,361 thyroid FNA samples. These four Taiwanese women presented with nodular goiter and foci of hematopoietic elements by thyroid FNA without any chronic disease of hematopoietic tissue or any evidence of a thyroid malignancy. PMID: 29317181 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
A 24-year-old man was referred to the haematologists for investigation of unexplained anaemia on the background of a 6-month history of exertional breathlessness, mild cough and night sweats. Investigations revealed iron-deficiency anaemia (haemoglobin 94 g/L), thrombocytosis and markedly elevated inflammatory markers (C-reactive protein (CRP) 235 mg/L). A CT scan of his chest identified a large expansile filling defect within the left main pulmonary artery, almost entirely occluding the left-sided pulmonary circulation, which had high-grade 18F-fluorodeoxyglucose (FDG) uptake on a subsequent positron emission to...
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Images in Thorax, Lung neoplasms, Lung cancer (oncology), Screening (oncology), Lung cancer (respiratory medicine), Cardiothoracic surgery, Radiology (diagnostics) Chest clinic Source Type: research
A 83-year-old man was admitted to our hospital with upper abdominal pain and anemia. Ultrasonography revealed a 78-mm hypoechoic mass in the head and body of the pancreas. Computed tomography showed a mass that was of lower contrast, and was penetrated by the celiac artery and superior mesenteric artery. On endoscopic ultrasonography, the surface was smooth, the margin was clear, internal echogenicity was heterogeneous, and there was no lateral shadow. Endoscopic retrograde pancreatography did not show stenosis or obstruction of the main pancreatic duct.
Source: Pancreatology - Category: Gastroenterology Authors: Source Type: research
Conclusions Thyroidal EMH is an extremely uncommon finding. Clinical and sonographic features are nonspecific. Thyroid EMH is usually an incidental finding, most likely related to mature osseous metaplasia. An occasional association with hematologic disease has been reported, however. To date, there does not appear to be any association with thyroid malignancy and surgery is typically not indicated. Therefore, recognition at the time of FNA is essential.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
A 62-year-old man presented with a 3-month history of diarrhea (10–14 nonbloody stools/d), anorexia, and lethargy. Physical examination showed euvolemia and hyperpigmentation (Figure A) of buccal mucosa/lips, palmar creases, knuckles, and a scar on his back. His blood pressure was 110/76 mm Hg, with a postural decrease of 22/10 mm Hg. On evaluation, he had anemia (hemoglobin level, 9.6 g/dL) and hyponatremia (serum sodium level, 122 mmol/L). Serum and urine osmolality were 262 and 380 mOsmol/L, respectively, and urine spot sodium level was 46 mmol/L.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Electronic Image of the Month Source Type: research
We present the case of a 7‐year‐old Cameroonian girl with sickle cell disease (SCD) who presented with progressive abdominal distension, fever, severe anemia, respiratory distress, and fatigue. Abdominal ultrasound showed a 15.3 cm × 11.5 cm × 15.5 cm solid echogenic mass within the left lobe of the liver. Fine‐needle aspiration showed features of extramedullary hematopoiesis (EMH). Despite transfusions, antibiotics, and initiation of hydroxyurea the patient died of respiratory failure during the hospital stay. There is a paucity of information on EMH in the pediatric sickle cell population, especially fr...
Source: Pediatrics International - Category: Pediatrics Authors: Tags: Patient Report Source Type: research
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