Biomarker Detection Improves in Alzheimer's and CTE Biomarker Detection Improves in Alzheimer's and CTE

Dr Alan Jacobs discusses the clinical implications of an ultrasensitive technique for detecting tau protein.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery Commentary Source Type: news

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Publication date: Available online 16 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Padraig J. Flannery, Eugenia TrushinaAbstractMitochondrial dysfunction is now recognized as a contributing factor to the early pathology of multiple human conditions including neurodegenerative diseases. Mitochondria are signaling organelles with a multitude of functions ranging from energy production to a regulation of cellular metabolism, energy homeostasis, stress response, and cell fate. The success of these complex processes critically depends on the fidelity of mitochondrial dynamics that include the ability of mitoch...
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
AbstractLymphangiogenesis is associated with some pathological conditions such as inflammation, tissue repair, and tumor growth. Recently, a paradigm shift occurred following the discovery of meningeal lymphatic structures in the human central nervous system (CNS); these structures may be a key drainage route for cerebrospinal fluid (CSF) into the peripheral blood and may also contribute to inflammatory reaction and immune surveillance of the CNS. Lymphatic vessels located along the dural sinuses absorb CSF from the adjacent subarachnoid space and brain interstitial fluid via the glymphatic system, which is composed of aqu...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
MicroRNAs (miRNAs) are small non-coding nucleic acids able to post-transcriptionally regulate gene expression by binding to complementary sequences of target messenger RNA (mRNA). It has been estimated that at least 1% of the human genome encodes miRNA and every miRNA can regulate up to 200 mRNAs. These findings suggest that dysregulation of miRNA expression could be associated with several human pathological conditions including central neurological disorders. Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. The characteristic symptoms are a progressive ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
As researchers continue to hunt for ways to treat or prevent Alzheimer ’s disease, one study has shown promise in slowing the progression of the disease.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
Circadian rhythm disturbances in older adults may be markers of Alzheimer disease and its progression, new research suggests.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Researchers don't know whether the finding related to the drug nilvadipine can translate into any benefits for patients. But future studies should look into that possibility, they said.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Changes to two kinds of sleep brain waves that tend to occur with age predict the build up of tau tangles and beta-amyloid plaques -harbingers of Alzheimer's - a new UC Berkeley study suggests.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Scientists find a key difference between Alzheimer's and frontotemporal dementia: the latter affects a person's 'moral emotions' while the former does not.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
The drug nilvadipine, used to treat hypertension, may bring hope in the fight to combat Alzheimer's disease, new research shows.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
A study by Radboud University in the Netherlands found the hypertension medication Nilvadipine widens arteries, which allows more oxygen-rich blood to reach the brain.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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