Hyperthermic intraperitoneal chemotherapy (HIPEC) in combined treatment of locally advanced and intraperitonealy disseminated gastric cancer: A retrospective cooperative Central ‐Eastern European study

ConclusionsGC patients with limited peritoneal metastases can benefit from CRS  + HIPEC. Hyperthermic intraperitoneal chemotherapy could be an effective method of adjuvant treatment of GC with a high risk of intraperitoneal progression. No long‐term survival may be expected after palliative approach to HIPEC.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Sharing a poster presentation done in Medcon2019 by Harika B 1styear PG& DR.ANV Prasad, Associate Professor NRI Institute of Medical Sciences CT Findings: Severe ascites seen. Multiple small enhancing nodules seen in the parietal peritoneum, visceral peritoneum and omentum with predominant pelvic distribution.Heterogeneously enhancing lesion of 3x2.1x1.8cm seen in RIF. Appendix is not seen separately from the lesion. Final Impression of Peritoneal carcinomatosis (pseudomyxoma peritoni) - likely due to mucinous adeno Ca. appendix.Peritoneal carcinomatosis(PC)  is the term given to malignant tumour seeding of ...
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs
To the Editor The article by Guo et al presents initial findings for the SEIPLUS study, a randomized clinical trial exploring the value of extensive intraoperative peritoneal lavage (EIPL) for treatment of locally advanced gastric cancer. As highlighted by Levine in an accompanying Invited Commentary, the accrual for this trial occurred during a remarkably short period, and EIPL appears to be a simple, safe, and low-cost method to decrease the peritoneal metastases rates.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 31 July 2019Source: European Journal of Surgical OncologyAuthor(s): M. Yu Reutovich, O.V. Krasko, O.G. SukonkoAbstractBackgroundEvaluation of hyperthermic intraperitoneal chemotherapy (HIPEC) in reducing metachronous peritoneal metastases (MPM) risks in patients with resectable serosa-invasive gastric cancer.Materials &methodsBetween 2008 and 2016, 154 patients with gastric cancer (stage IIB-IIIC) were randomly assigned to two groups: 76 patients underwent HIPEC (cisplatin 50 mg/m2 + doxorubicin 50 mg/m2, 42 °C, 1 h) combined with radical surgery (HIPEC group)...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conditions:   Gastric Adenocarcinoma;   Gastric Cancer;   Esophagogastric Junction;   Peritoneal Carcinomatosis Interventions:   Drug: Paclitaxel;   Drug: Capecitabine;   Device: BardPort Titanium Implanted Port withPeritoneal Catheter Sponsor:   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsGastric cancer with peritoneal metastases was successfully treated with a combination of gastrectomy plus intraperitoneal and systemic chemotherapy. Further studies using this simplified approach may be indicated.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Background: Peritoneal carcinomatosis is a common metastatic pattern in ovarian, gastric, colorectal and appendiceal cancer; systemic chemotherapy is the current standard of care for peritoneal metastatic disease; however, in a subset of patients its beneficial effect remains questionable. More effective perioperative chemotherapy is needed. Materials and Methods: PIPAC is a new treatment that applies chemotherapeutic drugs into the peritoneal cavity as an aerosol under pressure. It's a safe and feasible approach that improves local bioavailability of chemotherapeutic drugs as compared with conventional intraperitoneal ch...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Sequencing of whole exome and transcriptome of peritoneal carcinomatosis (PC) in patients with gastric adenocarcinoma (GAC) has given novel insights and opened up new therapeutic opportunities, according to Texas-based researchers.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Abstract The multimodal treatment of limited peritoneal metastases may improve prognosis in selected patients (pseudomyxoma peritonei, malignant peritoneal mesothelioma, colorectal, gastric and ovarian cancer) provided complete cytoreduction can be performed. Additive intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) is often performed. If the treatment is undertaken in experienced (and certified) centres, associated mortality is low. Intrapleural hyperthermic chemoperfusion (HITOC) can be performed in patients with pleural malignancies, mainly for malignant pleural mesothelioma or metastases from a...
Source: Zentralblatt fur Chirurgie - Category: Surgery Authors: Tags: Zentralbl Chir Source Type: research
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