Generic extraction medium: From highly polar to non-polar simultaneous determination.

Generic extraction medium: From highly polar to non-polar simultaneous determination. Anal Chim Acta. 2019 Aug 20;1066:1-12 Authors: Zeinali S, Khalilzadeh M, Bagheri H Abstract Sample preparation for non-target analysis is challenging due to the difficulty in the extraction of polar and non-polar analytes simultaneously. Most commercial solid sorbents lack the proper comprehensiveness for extraction of analytes with different physiochemical properties. A possible key is the combination of hydrophobic polymer and hydrophilic surface functional groups in solid based extraction methods in order to generate the susceptibility for retaining both polar and non-polar analytes. To pursue this goal, in this study, four polar groups including NH2, NO2, COOH, and COCH3 were chemically bound to Amberlite XAD-4 substrate in order to prepare a generic extraction platform. To validate the applicability of extractive phases, 22 analytes possessing wide range of polarities (LogP range between -2 and +7) were chosen for extraction using the synthesized polymers by online micro solid phase extraction (μ-SPE) and further analyzed with high-performance liquid chromatography and UV-Vis detection (HPLC-UV). The recovery data were compared with commercial sorbents by t-test, principal component analysis (PCA) and hierarchical cluster analysis (HCA). Amberlite XAD-4 modified with COOH group (XAD-COOH) revealed extraction efficiencies statistically better...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research