Model investigations for vanadium-protein interactions: Synthesis, characterization and antidiabetic properties

Publication date: Available online 27 April 2019Source: Inorganica Chimica ActaAuthor(s): N. Patel, A.K. Prajapati, R.N. Jadeja, R.N. Patel, S.K. Patel, Vivek K.Gupta, I.P. Tripathi, N. DwivediAbstractReaction of NNO donor Schiff bases with vanadyl sulphate afforded the complexes viz., [VO(L1)(H2O)]NO3 1, [VO(L2)(H2O)]NO3 2, [VO(L2)(ImH)2]SO4·H2O 3 and [VO(L1)ImH]NO3 4 (where, L1 = Acetic acid (2-hydroxy-3-methoxy-benzylidene)-hydrazide and L2 = 5-bromo-2-[(E)-(pyridine-2-ylhydrazono)methyl]phenol). In complex 3 the oxidation state of vanadium was found to be +5, while in rest all complexes it was +4. The crystal structure of complex 3 was solved by single crystal X-ray analysis. In addition to synthesis, optical, infrared and electrochemical properties of these complexes were also carried out. Electron paramagnetic spectra of oxidovanadium(IV/V) complexes is reported as well. Docking experiments were performed to study the molecular binding behaviour of all complexes with α-glucosidase enzyme. An antidiabetic feature like α-amylase and α-glucosidase inhibition studies made them promising candidates as inhibitors of insulin enzyme.Graphical abstract
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research