Establishment of Novel Technical Methods for Evaluating Brain Edema and Lesion Volume in Stroked Rats: a Standardization of Measurement Procedures.

Establishment of Novel Technical Methods for Evaluating Brain Edema and Lesion Volume in Stroked Rats: a Standardization of Measurement Procedures. Brain Res. 2019 Apr 23;: Authors: Boyko M, Zvenigorodsky V, Grinshpun J, Shiyntum HN, Melamed I, Kutz R, Shelef I, Brotfain E, Frank D, Zlotnik A Abstract Stroke plays a role in high morbidity and mortality. Deciphering its mechanisms and pathophysiology is critical for the creation of new drugs and therapies. Most of the previous animal models of stroke, aimed at identifying the extent and location of brain injury following stroke, require animal sacrifice, which, besides ethical considerations, also negates the ability for follow up studies with the same rats. Because of these failures, the useof clinicalmagnetic resonance scanners forevaluatingsmall animal models has been increasing. Magnetic resonance imaging scanners used particularly for small-bore animals are eligible for use in high-resolution magnetic resonance imaging of rodent brains. However, high costs and scarcity factor heavily in the rare availability of these scanners. In our investigation, we sought to establish a unitary magnetic resonance imaging protocol for stroke assessment in rats. We made use of a 3-Tesla magnetic resonance imaging clinical scanner, as well as another clinical equipment, with the purpose of increasing its reproducibility. The results of inquest validated a new magnetic resonance imaging protocol, ...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research