Monoaminergic regulation of nociceptive circuitry in a Parkinson's disease rat model.

Monoaminergic regulation of nociceptive circuitry in a Parkinson's disease rat model. Exp Neurol. 2019 Apr 24;: Authors: Campos ACP, Berzuino MB, Hernandes MS, Fonoff ET, Pagano RL Abstract Pain is a common nonmotor symptom of Parkinson's disease (PD) that remains neglected and misunderstood. Elucidating the nondopaminergic circuitry may be key to better understanding PD and improving current treatments. We investigated the role of monoamines in nociceptive behavior and descending analgesic circuitry in a rat 6-hydroxydopamine (6-OHDA)-induced PD model and explored the resulting motor dysfunctions and inflammatory responses. Rats pretreated with noradrenaline and serotonin reuptake inhibitors were given unilateral striatal 6-OHDA injections and evaluated for mechanical hyperalgesia and motor impairments. Through immunohistochemistry, the number and activation of neurons, and the staining for astrocytes, microglia and enkephalin were evaluated in specific brain structures and the dorsal horn of the spinal cord. The PD model induced bilateral mechanical hyperalgesia that was prevented by reuptake inhibitors in the paw contralateral to the lesion. Reuptake inhibitors also prevented postural immobility and asymmetric rotational behavior in PD rats without interfering with dopaminergic neuron loss or glial activation in the substantia nigra. However, the inhibitors changed the periaqueductal gray circuitry, protected against neuronal impairment in the locus c...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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It can be difficult to tease out the evidence-based science amidst the claims of successful adult stem cell-based treatments for a range of health problems from joint pain to Parkinson ’s disease, macular degeneration, and spinal cord injury. Even a number of well-respected medical centers now offer patients regenerative medicine treatments that use the patient’s own […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Genetics Primary Care Source Type: blogs
In this episode, Gabe talks with PsychCentral.com editor-in-chief Dr. John Grohol about the importance of planning for the end of life.  We all know that everybody dies, but at the same time, no one wants to think about their own inevitable death. Do you know how you would like the end of your life to go?  What if you needed to make that decision for a loved one? Do you know what they want? Would they want to be resuscitated? Do they want to die at home or in a hospital? Do you even know what kinds of decisions need to be made, or what the options are?  Listen in as Dr. John explains that there is a degre...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Death & Dying General LifeHelper The Psych Central Show Source Type: blogs
In conclusion, with study of the frailty syndrome still in its infancy, frailty analysis remains a major challenge. It is a challenge that needs to be overcome in order to shed light on the multiple mechanisms involved in the pathogenesis of this syndrome. Although several mechanisms contribute to frailty, immune system alteration seems to play a central role: this syndrome is characterized by increased levels of pro-inflammatory markers and the resulting pro-inflammatory status can have negative effects on various organs. Future studies should aim to better clarify the immune system alteration in frailty, and seek to esta...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: LBP affected walking, sleeping, standing, and lifting in this small sample of people with mild to moderate PD. Greater LBP-related disability was associated with greater motor sign severity, lower physical activity level, and lower QOL in people with PD. PMID: 31343700 [PubMed - as supplied by publisher]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: Phys Ther Source Type: research
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ánchez As the leading causes of human disability and mortality, neurological diseases affect millions of people worldwide and are on the rise. Although the general roles of several signaling pathways in the pathogenesis of neurodegenerative disorders have so far been identified, the exact pathophysiology of neuronal disorders and their effective treatments have not yet been precisely elucidated. This requires multi-target treatments, which should simultaneously attenuate neuronal inflammation, oxidative stress, and apoptosis. In this regard, astaxanthin (AST) has gained growing interest as a multi-target pharmac...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
CONCLUSIONThese results demonstrated that PS and C&A are associated with severe impairment of back functions and pain. Rehabilitation programs for PwPD and PS, and C&A should include spine alignment and postural training. PMID: 31177242 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
´╗┐ Rachel Star Withers is a speaker, YouTuber, and lives with schizophrenia. She is also a professional stunt woman and tends to describe herself as a “schizo stunt girl.”     In this episode, Rachel tells us a little of her history with the disease and details how she first started in mental illness activism.  Originally meant to just help other people with schizophrenia know that they were not alone, her YouTube channel, RachelStarLive, has become the longest existing chronicle of a personal experience with schizophrenia.  Listen Now! SUBSCRIBE &REVIEW   Guest information for &...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Peer Support Podcast Schizophrenia The Psych Central Show Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abbott Laboratories and the National Institutes of Health have formed an alliance to evaluate applications that could help treat chronic pain and progressive movement disorders, like Parkinson’s disease. The collaboration is a part of NIH’s BRAIN (Brain Research through Advancing Innovative Neurotechnologies) initiative to accelerate advancements in neuroscience research. The agreement specifically calls for NIH to use the Abbott Park, IL-based company’s neuromodulation technologies for research related to these NIH initiatives to explore their application for chronic p...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
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