Ivantis and Glaukos Clash in 1st Head-to-Head MIGS Trial

A study accepted for publication in the journal Ophthalmology could give Ivantis a competitive advantage against one of the top players in the micro invasive glaucoma surgery space.  Dubbed, “COMPARE,” the study pitted Ivantis’ Hydrus Microstent against two Glaukos iStent Trabecular Micro-bypass stents, for the treatment of open-angle glaucoma in a standalone procedure. Irvine, CA-based Ivantis said the study included 152 patients with mild to late-moderate stage disease and no previous glaucoma surgery. The study was conducted at 12 centers in nine countries outside of the US. It was designed to compare the safety and effectiveness of both devices for lowering IOP and reducing eye-drop medication. Some of the findings show that 47% of eyes in the Hydrus Microstent group were medication free, compared to 24% of eyes in the two iStent group. The findings also show medication use was reduced on average by 1.6 medications, or 61%, in the Hydrus Microstent group, compared to a reduction of one medication, or 37%, in the two iStent group. In addition, 73% of patients receiving the Hydrus Microstent achieved at least a 20% reduction in IOP while on fewer medications, compared to 47% of the two iStent eyes. Randy Craven, MD, Chief, Wilmer Eye Institute at Johns Hopkins University in Bethesda, MD, and an investigator in the trial said the COMPARE Trial is a necessary and highly anticipated study. "It i...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news

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Authors: Izquierdo Villavicencio JC, Agudelo Arbelaez N, Lastra BR, Ramirez I, Quezada F, Ponte MC, Cañola L, Mejias Smith J Abstract Purpose/Objective: To evaluate the effectiveness of combined phacoemulsification, viscogoniosynechialysis (VGSL), and endocyclophotocoagulation (ECP) in patients with moderate chronic angle-closure glaucoma (CACG) with peripheral anterior synechia (PAS) ≥90 not controlled with glaucoma medications and previous iridotomy yag laser. Materials and Methods: We retrospectively reviewed records from patients with cataract and uncontrolled chronic angle-closure glaucoma despit...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
AbstractPurposeTo compare the efficacy and safety of combined cataract extraction and either excisional goniotomy performed with the Kahook Dual Blade (KDB; phaco-KDB group) or single iStent trabecular bypass implantation (phaco-iStent group) in eyes with mild to moderate glaucoma and visually significant cataract.MethodsThis was a retrospective analysis of 315 eyes from 230 adults with mild or moderate glaucoma treated with one or more intraocular pressure (IOP)-lowering medications (190 eyes of 134 subjects in the phaco-KDB group and 125 eyes of 96 subjects in the phaco-iStent group) that required no subsequent surgical ...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Abstract PURPOSE: To determine the incidence, timing and risk factors for glaucoma and visual axis opacification development following surgery for congenital cataract in the first year of life. METHODS: A prospective case series of all cataract surgery performed in Temple Street Children's University Hospital over a 28-year period was conducted. A total of 93 subjects (135 eyes) were analysed. Sixty-two eyes had a primary intraocular lens inserted at the time of surgery; 73 eyes were aphakic. We recorded patient demographics, age at surgery, length of follow-up, rates and time to diagnosis of glaucoma and rat...
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
The effect of cataract surgery on IOP in patients with primary open-angle glaucoma (POAG) is a subject of debate. We investigated the effect of cataract surgery by phacoemulsification on intraocular pressure (...
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
CONCLUSION: We present a rare presentation of phaco-antigenic glaucoma following an uncomplicated cataract surgical procedure with good results following timely intervention. PMID: 31282196 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
We have read with great interest the article by Kim and associates.1 Cataract surgery is regarded especially beneficial in glaucoma patients based on its potential in attenuating intraocular pressure (IOP) and improving visual field (VF) reliability and optic nerve head and nerve fiber imaging quality. However, cataract surgery in patients with glaucoma requires diligent peri- and postoperative care.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
Conditions:   Open Angle Glaucoma;   Ocular Hypertension Interventions:   Drug: Pilocarpine;   Drug: Ofloxacin;   Drug: Prednisolone Sponsor:   Montefiore Medical Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Meticulous control of perioperative and postoperative inflammation could have contributed to the favorable long-term outcomes of phacotrabeculectomy in UG, as compared with POAG.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
Conclusions: This study highlights the value of AS-OCT in exploring the positioning of trabecular bypass devices such as the iStent inject. Our study shows that more microstents than suggested by gonioscopy could be completely burrowed within the trabeculum. It also suggests that the surgical outcomes of cataract surgery combined with iStent inject implantation may be connected to the amplitude of device protrusion within the anterior chamber as well as the postoperative dimensions of the SC.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
Conclusions: The present case is the first to describe the unusual presentation of pseudoexfoliation in a young individual along with presenile cataract. Simultaneous occurrence of pseudoexfoliation with cataract could be due to previous intraocular surgery, iris trauma, possible low-grade inflammation, and high myopia in a predisposed eye. The clinician should be aware that although a rare condition, pseudoexfoliation can occur in the young and may be associated with presenile cataract.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Online Articles: Case Report/Small Case Series Source Type: research
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