Learned helplessness reveals a population at risk for depressive ‐like behaviour after myocardial infarction in mice

ConclusionsThe LH paradigm uncovered a subtle predisposition to depressive ‐like behaviour after MI, whereas testing for anhedonia and despair was insufficient to show a behavioural shift in mice. Therefore, we suggest an accumulating risk profile and a multiple‐hits hypothesis regarding the pathogenesis of co‐morbid depression after MI. Symptoms of LH may present a marker of subclinical depression after MI, the impact of which remains to be investigated. The proposed sequence of behavioural testing enables the mechanistic dissection of cardio‐psychogenic signalling in the future.

Source: ESC Heart Failure - April 25, 2019 Category: Cardiology Authors: Bastian Bruns, Thomas Schmitz, Nathalie Diemert, Chrysovalandis Schwale, Stefanie Maria Werhahn, Friederike Weyrauther, Peter Gass, Miriam Annika Vogt, Hugo Katus, Wolfgang Herzog, Johannes Backs, Jobst ‐Hendrik Schultz Tags: Original Research Article Source Type: research