Molecular progression of SHH-activated medulloblastomas

Source: Acta Neuropathologica - Category: Neurology Source Type: research

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The objective is to propose a global method relying on the combined analysis of radiological, clinical and epidemiological criteria, (taking into account the child’s age and the topography of the lesion) in order to improve our histological approach in imaging, helping the management and approach for surgeons in providing information to the patients’ parents. Infratentorial tumors are the most frequent in children, representing mainly medulloblastoma, pilocytic astrocytoma and brainstem glioma. Pre-surgical identification of the tumor type and its aggressiveness could be improved by the combined analysis of key...
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
Lucca Larkin, 10, from Radcliffe in Greater Manchester, developed headaches in August. He was diagnosed with a medulloblastoma brain tumour at the end of the month.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Dasgupta A, Gupta T PMID: 31523387 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
NCI-CONNECT Medulloblastoma WorkshopAir date: 11/25/2019 8:00:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Abstract The repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) binds to repressor element 1/neuron-restrictive silencer element (RE1/NRSE) sites in the genome and recruits effector proteins to repress its target genes. Here, we developed the FlpTRAP system to isolate endogenously assembled DNA-protein complexes such as the REST/NRSF complex. In the FlpTRAP system, we take advantage of the step-arrest variant of the Flp recombinase, FlpH305L, which, in the presence of Flp recognition target (FRT) DNA, accumulates as FRT DNA-protein adduct. The FlpTRAP system consists ...
Source: Analytical Biochemistry - Category: Biochemistry Authors: Tags: Anal Biochem Source Type: research
Conditions:   CNS Tumors;   Meningioma;   Esthesioneuroblastoma;   Hemangioblastoma;   Medulloblastoma;   Paraganglioma;   Pituitary Adenoma Intervention:   Diagnostic Test: Ga68-DOTATATE-PET/MRI Sponsors:   Weill Medical College of Cornell University;   Novartis Pharmaceuticals Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Medulloblastomas present generally a-specifically as a fast-evolving posterior fossa tumor. Medical literature is poor concerning clinical features of medulloblastomas and their potential significance. In the present study, we reviewed 91 pediatric observations of medulloblastomas treated in Lille between 1997 and 2017. Clinical and epidemiological variables were collected and intercorrelated. They were also compared with anatomical and pathological findings, and outcome, with the aim of defining clinical-pathological entities. We also compared the group with 32 cases of posterior fossa ependymoma and 130...
Source: Neuro-Chirurgie - Category: Neurosurgery Authors: Tags: Neurochirurgie Source Type: research
Publication date: Available online 29 August 2019Source: Cancer CellAuthor(s): Liguo Zhang, Xuelian He, Xuezhao Liu, Feng Zhang, L. Frank Huang, Andrew S. Potter, Lingli Xu, Wenhao Zhou, Tao Zheng, Zaili Luo, Kalen P. Berry, Allison Pribnow, Stephanie M. Smith, Christine Fuller, Blaise V. Jones, Maryam Fouladi, Rachid Drissi, Zeng-Jie Yang, W. Clay Gustafson, Marc RemkeSummaryProgenitor heterogeneity and identities underlying tumor initiation and relapse in medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we demonstrated a developmental hierarchy of progenitor pools in Sonic Hedgehog (SHH) me...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Toni Ilsley's son Charlie, now 12, from Reading, was diagnosed with the brain tumour medulloblastoma when he was just eight years old in 2015. It spread to his spine last year.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The 13-year-8-month-old boy suffered from lower back pain 2 weeks ago and progressive right lower limb weakness and numbness from bilateral feet ascending to the lumbar region since 4 days ago. There was no accompanying headache, vomit, and bowel or bladder dysfunction. Neurologic examination revealed right lower limb weakness with muscle power grade 1/5 distally and 3/5 proximally and diminished sensations below T7 dermatome. Furthermore, the anal tone was mildly loose. Deep tendon reflex of right lower limb increased.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Images Source Type: research
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