Cabergoline for the Treatment of Chronic Pain Due to Endometriosis

Condition:   Endometriosis Interventions:   Drug: Cabergoline 0.5 MG;   Drug: Placebo - Cap Sponsors:   Boston Children’s Hospital;   Brigham and Women's Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionThe video demonstrates the feasibility of simultaneous laparoscopic and cystoscopic approach for excision of a bladder endometriotic nodule. Marking the nodule by simultaneous cystoscopy and laparoscopy before excision helps in removing the disease completely and avoiding unnecessary normal bladder wall excision, thus reducing the risk of recurrence and resultant small bladder symptoms.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Abstract Neurotrophins (NTs), particularly Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF), have attracted increasing attention in the context of visceral function for some years. Here, we examined current literature and produced a thorough review on the subject. After initial studies linking NGF to cystitis, it is now well-established that this neurotrophin (NT) is a key modulator of bladder pathologies, including Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS. NGF is upregulated in bladder tissue and its blockade results i...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
The modulation of endometriosis by lncRNA MALAT1 via NF-κB/iNOS. Eur Rev Med Pharmacol Sci. 2019 May;23(10):4073-4080 Authors: Yu J, Chen LH, Zhang B, Zheng QM Abstract OBJECTIVE: Endometriosis (Ems) is one benign disorder that frequently leads to chronic pelvic pain, dysmenorrhea or even infertility. Featured as the ectopic growth of active endometrial tissues on tissues beyond the muscular layer, Ems has complicated pathogenesis mechanisms that are not fully illustrated. Long non-coding (lnc) RNA MALAT1 participates in various biological activities, including cell growth, proliferation, apoptos...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Chronic pain has been found to be associated with structural and functional changes in the regions of the brain that are involved in the cognitive and emotional modulation of pain. These neurological changes contribute to the maintenance of pain, creating a vicious self-perpetuating circle. Evidence of these neurological changes has been found in several chronic pain syndromes1,21,29,37,46,77,79; however, endometriosis-related pelvic pain was still not comprehensively studied in this context. Endometriosis is a gynecologic condition that affects up to 15% of reproductive-aged women worldwide, constituting the most common c...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Publication date: Available online 27 May 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Aurélie Comptour, Bruno Pereira, Céline Lambert, Pauline Chauvet, Anne-Sophie Gremeau, Jean-Luc Pouly, Michel Canis, Nicolas BourdelABSTRACTStudy objectiveTo investigate predictive factors for change in quality of life (QoL) between pre and post-operative periods in patients with endometriosisDesignProspective and multicenter cohort studySetting5 districts including a tertiary referral center, private and general public hospitalsPatient981 patients, aged 15-50 years, underwent laparoscopic treatment (prefe...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionsThis study shows that RA, endometriosis and IBD are all risk factors for later fibromyalgia and chronic widespread pain, consistent with a hypothesis of central sensitization as an effect of a painful underlying condition.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion Using a validated method, the VAS, we have studied the pain experienced by a group of patients with a history of endometriosis and observed that smoking habit and BMI did not influence the VAS scores, and that dysmenorrhea was associated with the highest perception of pain.Resumo Objetivo A endometriose é uma doença complexa, e a dor é um componente importante da enfermidade. Um dos métodos mais utilizados para avaliar a dor é a escala visual analógica (EVA). O objetivo da presente pesquisa foi estudar a dor sentida pelas pacientes que se referiram à nossa unidade...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Dienogest has been shown to substantially improve endometriosis-associated symptoms such as debilitating chronic pelvic pain, and in turn, health-related quality of life (HRQoL). To date, there is no data on p...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
This study supports the hypothesis that BDNF and S100B neuromodulators present different serum levels according to the background disease associated to the chronic pain. These have the potential to be studied as markers of active disease or treatment evolution.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Thank you for your letter entitled “Years of unjustified hypoestrogenism, fear, and stress will not improve the management of chronic pelvic pain!” The goal of our manuscript entitled “Clinical diagnosis of endometriosis: a call to action” 1 was to highlight the current unacceptable delay in diagnosis and to encourage a focu s on pain, functioning, and quality of life, with or without a previous surgical diagnosis endometriosis. We agree with your statement “Even minimally invasive surgery is too invasive to manage minimal endometriosis, which is not always progressive and may heal during...
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Letter to the Editors Source Type: research
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