Use Profile of Magnesium Sulfate in Anesthesia in Brazil

Conclusions: Magnesium sulfate is an important adjuvant drug in the practice of anesthesia, with several clinical effects and a low incidence of adverse events when used at recommended doses.

Introduction
Magnesium is the fourth most common ion in the body, and it participates in several cellular processes, including protein synthesis, neuromuscular function and stability of nucleic acid, as well as regulating other electrolytes such as calcium and sodium. Magnesium acts as a cofactor in protein synthesis, neuromuscular function and stability and the function of nucleic acids. It is a component of adenosine 5-triphosphatases and an endogenous regulator of other electrolytes. It is a calcium antagonist because it is a non-competitive inhibitor of calcium channels with inositol triphosphate. Magnesium modulates sodium and potassium currents and, as a consequence, interferes with the transmembrane potential. It is a central nervous system depressant, antagonizing N-methyl-D-aspartate (NMDA) and inhibiting the release of catecholamines (Herroeder et al., 2011).
Some studies have shown that the use of magnesium sulfate as an adjunct in anesthesia reduces intraoperative consumption of anesthetics (Koinig et al., 1998; Seyhan et al., 2006; Ryu et al., 2008; Forget and Cata, 2017). It also provides better analgesia and reduces the amount of morphine used in the postoperative period (Mentes et al., 2008; Dabbagh et al., 2009; Hwang et al., 2010). Studies in clinical practice ...

Source: Frontiers in Pharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research