Three new alkaloids from the roots of Sophora tonkinensis

AbstractA new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and3), together with two known alkaloids (4 and5), were isolated from the roots ofSophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolute configuration of1 was established by electronic circular dichroism data. Herein, is the first report of β-carboline alkaloid in the plant of genusSophora. In addition, the cytotoxic activities against HepG2 cells of compounds1–5 were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Among them, compounds1,4 and5 showed a weak cytotoxic activity with IC50 values of 87.4  ± 7.1, 91.8 ± 3.5 and 48.9 ± 5.2 μM, respectively.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research

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