Ovine Pulmonary Adenocarcinoma: A Unique Model to Improve Lung Cancer Research

Ovine Pulmonary Adenocarcinoma: A Unique Model to Improve Lung Cancer Research Mark E. Gray1,2*, James Meehan2,3, Paul Sullivan4, Jamie R. K. Marland4, Stephen N. Greenhalgh1, Rachael Gregson1, Richard Eddie Clutton1, Carol Ward2, Chris Cousens5, David J. Griffiths5, Alan Murray4 and David Argyle1 1The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom 2Cancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 3School of Engineering and Physical Sciences, Institute of Sensors, Signals and Systems, Heriot-Watt University, Edinburgh, United Kingdom 4School of Engineering, Institute for Integrated Micro and Nano Systems, The King's Buildings, Edinburgh, United Kingdom 5Moredun Research Institute, Pentlands Science Park, Midlothian, United Kingdom Lung cancer represents a major worldwide health concern; although advances in patient management have improved outcomes for some patients, overall 5-year survival rates are only around 15%. In vitro studies and mouse models are commonly used to study lung cancer and their use has increased the molecular understanding of the disease. Unfortunately, mouse models are poor predictors of clinical outcome and seldom mimic advanced stages of the human disease. Animal models that more accurately reflect human disease are required for progress to be...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 9 July 2020Source: The Journal of Foot and Ankle SurgeryAuthor(s): Ahmet Emin Okutan, Muhammet Salih Ayas, Kerim Öner, Ahmet U─čur Turhan
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Publication date: September 2020Source: Journal of Orthopaedic Translation, Volume 24Author(s): Xiaolei Sun, Xueping Li, Hongzhao Qi, Xin Hou, Jin Zhao, Xubo Yuan, Xinlong Ma
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Authors: Dutra JDM, Lisboa QC, Ferolla SM, Carvalho CMML, Mendes CCM, Ferrari TCA, Couto CA Abstract Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histo...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Authors: Sánchez-Cuesta A, Cortés-Rodríguez AB, Navas-Enamorado I, Lekue JA, Viar T, Axpe M, Navas P, López-Lluch G Abstract Ubiquinol, the reduced form of Coenzyme Q10 (CoQ10), is a key factor in bioenergetics and antioxidant protection. During competition, professional soccer players suffer from considerable physical stress causing high risk of muscle damage. For athletes, supplementation with several antioxidants, including CoQ10, is widely recommended to avoid oxidative stress and muscle damage. We performed an observational study of plasma parameters associated with CoQ10 levels in...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p 
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Publication date: Available online 9 July 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Lucia La Sala, Livio Luzi, Antonio E. Pontiroli
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Authors: Martínez-Peinado N, Cortes-Serra N, Losada-Galvan I, Alonso-Vega C, Urbina JA, Rodríguez A, VandeBerg JL, Pinazo MJ, Gascon J, Alonso-Padilla J Abstract INTRODUCTION: Chagas disease treatment relies on the lengthy administration of benznidazole and/or nifurtimox, which have frequent toxicity associated. The disease, caused by the parasite Trypanosoma cruzi, is mostly diagnosed at its chronic phase when life-threatening symptomatology manifest in approximately 30% of those infected. Considering that both available drugs have variable efficacy by then, and there are over 6 million people infect...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Abstract The influence of magnesium on roasting vanadium slag was investigated by simulating the roasting process of vanadium by mixing V2O5 and MgO. The calcination products of V2O5 reacted with MgO at different temperatures which were characterized by X-ray diffraction (XRD), Thermogravimetry-differential scanning calorimetry (TG-DSC) and scanning electron microscope (SEM). There were two mass loss intervals, three endothermic peaks and one exothermic peak appearing during the reaction by the integrated thermal analysis as the temperature increased from room temperature to 1273.15 K. The samples of mixed V2O5 an...
Source: An Acad Bras Cienc - Category: Science Authors: Tags: An Acad Bras Cienc Source Type: research
Abstract To examine the association between phytase and xylanase in diets with nutritional adjustments on intestinal morphometry, serum biochemistry and microbiology of broilers, 250 broilers were evaluated in a completely randomized design with five treatments and five replicates. The following treatments were tested: positive control diet - without phytase or xylanase; negative control diet - with an energy reduction of 100 kcal/kg, without phytase or xylanase; and three diets containing xylanase and phytase and energy reductions of 50, 100 and 150 Kcal/kg. For all energy-reduced diets, the nutritional matrix of...
Source: An Acad Bras Cienc - Category: Science Authors: Tags: An Acad Bras Cienc Source Type: research
Publication date: Available online 8 July 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Abdelfattah Selim, Ameer A. Megahed, Sahar Kandeel, Abdelhamed Abdelhady
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
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