Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor
Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor Chiu-Min Lin1†, Ching-Fang Yu2,3†, Hsueh-Ya Huang1,4, Fang-Hsin Chen2,3,5, Ji-Hong Hong2,3,5 and Chi-Shiun Chiang1,6,7* 1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan 2Department of Radiation Oncology, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan 3Radiation Biology Research Center, Institute for Radiological Research, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan 4Education &Medical Research National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan 5Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan 6Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan 7Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan Tumor vasculatures and hypoxia are critical tumor micro-environmental factors associated with tumor response to the therapy and heterogeneous in both time- and location-dependent manner. Using a murine orthotopic anaplastic astrocytoma model, ALTS1C1, this study showed that brain tumor edge had a very unique microenvironment, having higher microvascular density (MVD) and better vessel function than the tumor core, but on the other hand was als...
Publication date: Available online 30 June 2020Source: Artificial Intelligence in MedicineAuthor(s): Danqing Hu, Shaolei Li, Zhengxing Huang, Nan Wu, Xudong Lu
Conclusions: Outdoor PM10 and O3 exposure was associated with reduction in FEV1 in atopic asthmatic and non-asthmatic children. PMID: 32597339 [PubMed - as supplied by publisher]
Authors: Koczwara B PMID: 32596806 [PubMed - as supplied by publisher]
Using laser excitation, expression microdissection (xMD) can selectively heat cancer cells targeted via immunohistochemical staining ...
Authors: Stevenson RB PMID: 32593344 [PubMed - in process]
CONCLUSION: Traditional techniques, like radiotherapy (RT) show decent results, although they cannot spare 100% the healthy tissues neighboring with the cancer ones. Targeted therapies, such as proton and photodynamic therapy (PT and PDT, respectively) present adequate outcomes, even though each one has its own drawbacks. In order to overcome these limitations, the combination of therapeutic modalities has been proposed and has already been showing promising results. At the same time, the recent advances in nanotechnology in the form of nanoparticles enhance cancer therapy, making multimodal treatments worthy of exploring ...
Authors: Chang CY, Lew WZ, Feng SW, Wu CL, Wang HH, Hsieh SC, Huang HM Abstract Background/Purpose: Wharton's jelly mesenchymal stem cells (WJMSCs) are well-known for use in nontissue-specific stem cell therapy. However, they can be a challenge for orthopedic used because they have low osteogenic differentiation ability. Several studies have found that static magnetic fields (SMFs) have positive effects on the osteogenesis of different stem cells. Nevertheless, whether SMFs have similar effects on WJMSC differentiation is unknown. Matrix vesicles are the critical characteristic of osteogenesis. Matrix vesicles serv...
Conclusions: Whole-brain irradiation causes delayed brain hypometabolism, which is not accompanied by white matter loss. Irradiated animals showed similar behavioral changes over time as control animals and therefore cerebral hypometabolism could not be linked to behavioral abnormalities. However, spatial memory seems to be associated with myelin density in irradiated rats. PMID: 32602390 [PubMed - as supplied by publisher]
Conclusion: No statistically significant radiation associations were observed among 114,270 nuclear weapons test participants followed for up to 65 y. The 95% confidence limits were narrow and exclude mortality risks per unit dose that are two to four times those reported in other investigations. Significantly elevated SMRs were seen for mesothelioma and asbestosis, attributed to asbestos exposure aboard ships. PMID: 32602389 [PubMed - as supplied by publisher]
Conclusion: Performing specialized tests to diagnose toxoplasma infection before starting treatment, in immunodeficiency patients who undergo chemotherapy, is necessary; therefore, these tests should be considered in therapeutic protocols. PMID: 32595708 [PubMed]
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