MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis

This study was carried out in accordance with the recommendations of the German laws of animal protection, Government of Unterfranken, Bavaria, Germany and in accordance with the recommendations by the National Institute of Health, UTSW Institutional Animal Care and Use Committee (IAUAC). Author Contributions KK, AnH, ET, SH, AlH, RH, WM-L, and JS planned and performed the experiments, RL, OS, and BS designed the study and planned and supervised the research project. AK performed microbiome analysis. KK and AnH wrote the manuscript. AS and NW provided genetically engineered MAdCAM-KO mice. RL and OS supervised the research and edited the manuscript. All authors read and approved the final manuscript. Funding OS was supported by a visting professorship from the IZKF Erlangen, Germany and parts of the study were funded by Roberta I. and Norman L. Pollock Fund (AK). Conflict of Interest Statement OS serves on the editorial boards of the Multiple Sclerosis Journal, and Therapeutic Advances in Neurological Disorders and has served on data monitoring committees for Pfizer and TG Therapeutics without monetary compensation. OS has advised EMD Serono and Genzyme and currently receives grant support from Sanofi Genzyme. OS received travel support from Shire. RL received compensation for activities with Bayer, Biogen, Genzyme, Merck, Novartis, Roche, and TEVA as well as research support from Biogen and Novartis. The remaining authors declare that the research was conducted in the...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research