Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain Regions Is Regulated in Response to Chronic Social Defeat Stress in Mice

In conclusion, the current study has identified A-to-I editing as another molecular mechanism of likely relevance to stress resiliency and susceptibility to CSDS in adult mice, in line with the growing appreciation for stress-induced regulation of RNA metabolism within the brain (21, 48, 49). Further investigation of the consequences of these editing changes is required at both the mRNA and protein levels to decipher the functional consequences of RNA editing following chronic stress.Ethics StatementThis study was carried out in accordance with the recommendations of the European Communities; Council Directive 2010/63/EU. The protocols were approved by the Animal Care and Use Committee of the Government of Upper Bavaria, Munich, Germany.Author ContributionsAD, KK, EL, and AC conceptualized and designed the experiments and wrote the manuscript. AD and EP conducted all animal experiments analyzed by AD. AD and KK conducted and analyzed all mmPCR-seq experiments. AD and FS conducted qPCR experiments analyzed by AD.Conflict of Interest StatementThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.AcknowledgmentsWe thank L. Tietze, B. Schmid, and D. Harbich for their technical support and A. Varga and the animal care team for their assistance with animal care. AC is the head of the Max Planck Society–Weizmann Institute of Science Laboratory for Experimental...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research