Nerve Growth Factor Serum Levels Are Associated With Regional Gray Matter Volume Differences in Schizophrenia Patients

This study aimed to investigate a potential correlation between NGF serum levels and brain structural differences in schizophrenia. Furthermore, a potential overlap between the results of a whole brain correlation analysis between GMV and NGF serum levels and the results of GMV reductions in schizophrenia patients were identified in a conjunction analysis.Materials and MethodsSubjectsEighteen schizophrenia patients from the Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, Aachen, Germany, and 19 gender- and age-matched healthy controls from the general population participated in the present study (Table 1). All subjects were of Caucasian descent and right-handed. Diagnosis of schizophrenia was established using the International statistical classification of diseases and related health problems (ICD-10) diagnostic criteria (code F20.X). Symptom severity in schizophrenia patients was measured using the Positive and Negative Syndrome Scale (PANSS) (63). Exclusion criteria for all subjects were 1) current substance or alcohol abuse or any diagnosed substance abuse or addiction in the past (ICD-10: F10.1 or .2 - 19.1 or .2), 2) severe medical conditions such as chronic or acute diseases (i.e., infections, allergies), 3) general contraindications to MRI scanning, 4) gross morphological changes on MRI such as cerebral atrophy, hydrocephalus, or previous injury, and 5) incomplete scanning. Subjects treated with benzodiazepines were not inc...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Authors: Quinlan R, Hill JA Abstract PURPOSE: To investigate the effects of supplementation with tart cherry juice (TCJ) on markers of recovery after intermittent exercise under habitual dietary conditions. METHODS: Using a randomized, single-blind, placebo (PLA)-controlled, independent-groups design, 20 team-sport players (8 male and 12 female; age 26 [4] y, height 175.4 [9.6] cm, body mass 70.2 [12.6] kg) were divided equally into 2 groups and consumed either TCJ or PLA twice per day for 8 consecutive days while following their normal dietary habits. Participants completed an adapted version of...
Source: International Journal of Sports Physiology and Performance - Category: Sports Medicine Tags: Int J Sports Physiol Perform Source Type: research
Authors: Schumacher L Abstract Collective cell migration is a key process in developmental biology, facilitating the bulk movement of cells in the morphogenesis of animal tissues. Predictive understanding in this field remains challenging due to the complexity of many interacting cells, their signalling, and microenvironmental factors - all of which can give rise to non-intuitive emergent behaviours. In this chapter we discuss biological examples of collective cell migration from a range of model systems, developmental stages, and spatial scales: border cell migration and haemocyte dispersal in Drosophila, gastrula...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Banerjee S, Marchetti MC Abstract Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate cell motility in development and physiology, a key biological question is how cells integrate molecular activities for force generation on multicellular scales. In this review we discuss recent advances in modeling collective cell migration using quantitative tools and approaches rooted in soft matter physics. We focus on theoretical models of cell aggregates as continuous active media, where the...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Ferrari A, Giampietro C Abstract Cells apply forces to their surroundings to perform basic biological activities, including division, adhesion, and migration. Similarly, cell populations in epithelial tissues coordinate forces in physiological processes of morphogenesis and repair. These activities are highly regulated to yield the correct development and function of the body. The modification of this order is at the onset of pathological events and malfunctions. Mechanical forces and their translation into biological signals are the focus of an emerging field of research, shaping as a central discipline i...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Achmat G, Leach L, Onagbiye SO Abstract BACKGROUND: Cardiometabolic disease (CMD) risk factors have reached epidemic proportions, with many people at risk of premature disability and death. There is insufficient data regarding the prevalence of CMD risk factors among firefighters in the Western Cape Province of South Africa. The purpose of this study was to examine the prevalence of CMD risk factors among South African firefighters in the Western Cape Province. Additional outcomes were to determine the relationship between BMI and CMD risk factors among firefighters. METHODS: A total of 219 healthy mal...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
Authors: Martini S, Conte A, Bottazzi S, Tagliazucchi D Abstract Meat lipids oxidation during digestion gives rise to a post-prandial oxidative stress condition, which negatively affects human health. Mediterranean Diet vegetables contain high amount of phenolic compounds, which potentially may reduce the oxidative phenomena during digestion. In vitro co-digestion of turkey meat with a typical Mediterranean Diet salad containing tomato, onion, black olives, extra-virgin olive oil (EVOO) and basil, dose-dependently reduced lipid peroxidation. Onion and EVOO were more effective in limiting oxidation than the other fo...
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC06528H, CommunicationChenyao Hu, Zupeng Chen, Fengyan Han, Zixia Lin, Xiaofei Yang Ultrasmall and homogeneous bimetallic PdXBi nanoalloys are well distributed on Vulcan carbon support by a facile, low-cost synthetic strategy. The electrochemical activity of as-prepared homogeneous PdXBi nanoalloy/carbon black nanocomposites is... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
[Thomson Reuters Foundation] It is often said that the human body needs water before it needs food. And the reality is that we need a lot of water in order to produce food.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Authors: Segerman F, Clarkson S, Sjöberg K Abstract Objective: The incidence of autoimmune diseases, especially inflammatory bowel disease (IBD), has increased substantially. Globally, there are vast differences varying from 0.2/105 in some Asian countries to over 80/105 in the Faroe Islands. Environmental factors have been suggested as triggers. The aim was to investigate the incidence and prevalence of IBD in the 33 municipalities in the county Scania in Southern Sweden, an area comprising 100 × 100 km with 1,274,069 inhabitants. Furthermore, we wanted to explore whether compounds ...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
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