Nerve Growth Factor Serum Levels Are Associated With Regional Gray Matter Volume Differences in Schizophrenia Patients

This study aimed to investigate a potential correlation between NGF serum levels and brain structural differences in schizophrenia. Furthermore, a potential overlap between the results of a whole brain correlation analysis between GMV and NGF serum levels and the results of GMV reductions in schizophrenia patients were identified in a conjunction analysis.Materials and MethodsSubjectsEighteen schizophrenia patients from the Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, Aachen, Germany, and 19 gender- and age-matched healthy controls from the general population participated in the present study (Table 1). All subjects were of Caucasian descent and right-handed. Diagnosis of schizophrenia was established using the International statistical classification of diseases and related health problems (ICD-10) diagnostic criteria (code F20.X). Symptom severity in schizophrenia patients was measured using the Positive and Negative Syndrome Scale (PANSS) (63). Exclusion criteria for all subjects were 1) current substance or alcohol abuse or any diagnosed substance abuse or addiction in the past (ICD-10: F10.1 or .2 - 19.1 or .2), 2) severe medical conditions such as chronic or acute diseases (i.e., infections, allergies), 3) general contraindications to MRI scanning, 4) gross morphological changes on MRI such as cerebral atrophy, hydrocephalus, or previous injury, and 5) incomplete scanning. Subjects treated with benzodiazepines were not inc...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Conclusions: Both user characteristics and parenting practices were significantly associated with adolescents' initial use of Aim2Be. These findings will help inform future e-health interventions increase user engagement by identifying the characteristics of individuals who are not accessing the intervention, as well as identifying factors of the household environment that support use. PMID: 32598175 [PubMed - as supplied by publisher]
Source: Childhood Obesity - Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research
Authors: Kulshrestha R, Dhanda H, Pandey A, Singh A, Kumar R Abstract INTRODUCTION: The diffuse parenchymal lung diseases (DPLD)/interstitial lung diseases (ILD) are progressive lung disorders with usually unclear etiology, poor long-term survival and no effective treatment. Their pathogenesis is characterized by alveolar epithelial cell injury, inflammation, epithelial-mesenchymal transition, and parenchymal fibrosis. Macrophages play diverse roles in their development, both in the acute phase and in tissue repair. AREAS COVERED: In this review, we summarize the current state of knowledge regarding the role of...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Therapeutic application of extracellular vesicles for musculoskeletal repair &regeneration. Connect Tissue Res. 2020 Jun 30;:1-16 Authors: Youssef El Baradie KB, Hamrick MW Abstract Traumatic musculoskeletal injuries are common in both the civilian and combat care settings. Significant barriers exist to repairing these injuries including fracture nonunion, muscle fibrosis, re-innervation, and compartment syndrome, as well as infection and inflammation. Recently, extracellular vesicles (EVs), including exosomes and microvesicles, have attracted attention in the field of musculoskeletal regeneration....
Source: Connective Tissue Research - Category: Research Tags: Connect Tissue Res Source Type: research
Authors: Roh YT, Song SW, Jeong C, Kang Y, Park IJ Abstract Lipofibromatous hamartoma (LFH) is a rare tumor of the peripheral nerves, which usually involves the median nerve. The authors reported on two rare cases of carpal tunnel syndrome due to LFH of the median nerve. A 49-year-old female patient complained of the mass and symptoms consistent with LFH. Magnetic resonance imaging (MRI) showed typical LFH findings. The symptoms were successfully ameliorated with carpal tunnel release and external neurolysis. A 37-year-old female patient complained of weakening thumb abduction and the mass where the MRI showed atyp...
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
CONCLUSIONS: The results of this study suggest that diet drinks have no adverse effect on teeth among US children. Additional well-designed longitudinal studies should be conducted to establish the effect of diet drinks on caries when consumed during childhood. PRACTICAL IMPLICATIONS: Although this study did not show an association between caries and diet drinks, dental practitioners should be cautious about recommending these drinks, as they have been linked to systemic diseases. In addition, the American Academy of Pediatrics and National Academy of Medicine do not recommend that children consume these beverages. ...
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Authors: Heir GM PMID: 32593342 [PubMed - in process]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Authors: Chang CY, Lew WZ, Feng SW, Wu CL, Wang HH, Hsieh SC, Huang HM Abstract Background/Purpose: Wharton's jelly mesenchymal stem cells (WJMSCs) are well-known for use in nontissue-specific stem cell therapy. However, they can be a challenge for orthopedic used because they have low osteogenic differentiation ability. Several studies have found that static magnetic fields (SMFs) have positive effects on the osteogenesis of different stem cells. Nevertheless, whether SMFs have similar effects on WJMSC differentiation is unknown. Matrix vesicles are the critical characteristic of osteogenesis. Matrix vesicles serv...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Conclusions: Whole-brain irradiation causes delayed brain hypometabolism, which is not accompanied by white matter loss. Irradiated animals showed similar behavioral changes over time as control animals and therefore cerebral hypometabolism could not be linked to behavioral abnormalities. However, spatial memory seems to be associated with myelin density in irradiated rats. PMID: 32602390 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Authors: Hosseini SM, Moshrefi AH, Esfandiyari A, Youssefi MR, Nassiri A Abstract According to the last information of IUCN Red List, Eurasian lynx has been endangered since 2010. The population of this animal is heavily affected by infectious parasites. Two adult Eurasian lynx (one male and one female) were illegally hunted and found dead in Parvar National Park, Semnan Province, Iran. After the autopsy, the tissue and parasite samples were collected from gastrointestinal tract and transferred to 70% alcohol. Samples were recovered and identified as Joyeuxiella spp. Sonsino, 1889. Tissue samples were taken from th...
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
Authors: Alver O, Baykara M, YÜrÜk M, TÜzemen NÜ Abstract Acanthamoeba species are vision-threatening agents by causing cornea infections known as Acanthamoeba keratitis. A 5 year-old kid with the complaints of erythema, eyelid edema, inflammation, limitation of eye movements in the right eye, and having no history of wearing contact lenses or trauma, was diagnosed of Acanthamoeba conjunctivitis through laboratory examinations in the Ophthalmology clinic. The visual sharpness of the patient improved after the treatment. A 44 year-old female patient suffering from pain, stinging, irritation, and ...
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
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