A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis, Including Pertactin Deficient Strains

This study was conducted in accordance with the recommendations and guidelines and under licenses approved by the Health Products Regulatory Authority of Ireland and Argentina. The protocol was approved by the Trinity College Dublin Animal Research Ethics Committee and the Ethical Committee for Animal Experiments of the Faculty of Science at La Plata National University (Argentina, approval number 004-06-15 and 003-06-15). Author Contributions DH and KM planned the study, interpreted data, and wrote the manuscript. MZ and MW planned the study, interpreted data, and edited the figures and manuscript. FC, EB, GM, and AM performed experiments and laboratory analyses. All authors approved the final manuscript. Funding This study was funded by a grant from the ANCPyT (PICT 2014-3617), CONICET and FCE-UNLP (Argentina) grants to DH and by a Science Foundation Ireland grant (16/IA/4468) to KM. DH, GM, and MZ are members of the Scientific Career of CONICET. FC and EB are fellows from CONICET. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2019.00125/full#suppl...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research