BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury
This study also identified the cardiac myocyte as a significant local source of BDNF, as cardiac myocyte-specific deletion of BDNF induced a similar cardiomyopathy phenotype. While these results do not exclude a role for other neurotrophins, particularly in injury states, they point to the requirement for continued, local synthesis of BDNF to maintain optimal cardiac function. A major, unresolved question relates to how the truncated TrkB isoform (TrkBT1) transduces the inotropic effects of BDNF, which will require additional study. A concurrent study evaluated the potential impact of the BDNF-mediated activation of the kinase active isoform of TrkB in the adult heart, by genetically deleting this isoform in cardiac myocytes (Feng et al., 2014). Using this approach, deficits in CaMKII activity were observed upon deletion of kinase active TrkB. While deficits in systolic function were observed, these were not significant enough to trigger chamber dilation or reduce ejection fraction. Interestingly, in models of cardiac failure (induced by transverse aortic constriction, or in hearts overexpressing G α q that display cardiac dilation), induction of the truncated isoform (TrkBT1) is observed, suggesting a compensatory mechanism to augment myocyte contractility (Figure 1). These studies are highly relevant as the field considers the use of BDNF-mimetics to enhance TrkB activation in central neurons for the treatment of mood disorders, regulation of food intake, and neurod...
Publication date: Available online 4 April 2020Source: Physiology &BehaviorAuthor(s): Kuei-Pin Huang, Charlotte C. Ronveaux, Trina A. Knotts, Jennifer R. Rutkowsky, Jon J. Ramsey, Helen E. Raybould
CONCLUSIONS: This study suggests that MTC is a more immunologically active tumor that has been previously reported. Patients with advanced MTC should be screened for targetable antigens and immune checkpoints to determine their eligibility for current clinical trials. Additional studies are necessary to fully characterize the antigenic potential of MTC and may encourage the development of adoptive T cells therapies for this rare tumor. PMID: 32242507 [PubMed - as supplied by publisher]
Jerome Adams reaches for second world war imageryNo White House briefing as president tweets insteadCoronavirus – US updatesCoronavirus – global updatesSee all our coronavirus coverageThe US surgeon general warned the country on Sunday that it will face a “Pearl Harbor moment” in the next week, with an unprecedented numbers of coronavirus deaths expected coast to coast.Related:Jared Kushner and his shadow corona unit: what is Trump's son-in-law up to?Continue reading...
The influence of the α/β ratio on treatment time iso-effect relationships in the central nervous system. Int J Radiat Biol. 2020 Apr 03;:1-25 Authors: Jones B, Klinge T, Hopewell JW Abstract Purpose: To investigate the influence of changes in α/β ratio (range 1.5-3 Gy) on iso-effective doses, with varying treatment time, in spinal cord and central nervous system tissues with comparable radio-sensitivity. It is important to establish if an α/β ratio of 2 Gy, the accepted norm for neuro-oncology iso-effect estimations, can be used.Methods: The rat spinal cor...
Publication date: Available online 4 April 2020Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Maharsh K. Patel, William Z. Stone, Bradley S. Schoch, Aimee M. Struk, Kevin W. Farmer, Thomas W. Wright, Joseph J. King
A HEART attack can happen to anyone, anywhere, at any time. How do you know if you're at risk of having one? What's the sign in your eyes that could signal the deadly condition?
Almost 8,500 of the U.S. ’s reported 310,000 coronavirus patients have died, and governors are hunting for scarce ventilators. In Finland, a stockpile dating to the Cold War proves timely.
In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional study was conducted on women with GH hospitalized in hospitals affiliated with Mashhad University of Medical Sciences, compared with healthy women admitted for normal delivery in the same centers during the study. Data were collected via Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) and Depression Anxiety Stress Scale (DASS) 21.Results: TEMPS-A revealed that scores anxious (P
Conclusion: This study provides evidence for blood pressure management in Chinese pregnant women. PMID: 32243195 [PubMed - as supplied by publisher]
Australia reported a sustained fall in new coronavirus infections and conducted the biggest peacetime maritime operation on Sydney Harbour on Saturday, refuelling foreign cruise ships before expelling them from local waters.
More News: Academia | Adenoviruses | Australia Health | Biology | Brain | Brain Cancers | Cardiac Catheterization | Cardiology | Cardiomyopathy | Cardiovascular | Cholesterol | Coronary Heart Disease | Diets | Eating Disorders & Weight Management | Finland Health | Funding | Ganglions | Gastroschisis Repair | Genetics | Heart | Heart Attack | Heart Disease | Heart Transplant | Hemorrhagic Stroke | Hormones | Hypertension | Laboratory Medicine | Men | Nanotechnology | National Institutes of Health (NIH) | Neurology | Nutrition | Obesity | Pathology | Perfusion | Perinatology & Neonatology | Pharmaceuticals | Physiology | Psychiatry | Reflex Sympathetic Dystrophy | Reproduction Medicine | Respiratory Medicine | Statistics | Stem Cell Therapy | Stem Cells | Study | Thrombosis | Transplants | USA Health