BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury

This study also identified the cardiac myocyte as a significant local source of BDNF, as cardiac myocyte-specific deletion of BDNF induced a similar cardiomyopathy phenotype. While these results do not exclude a role for other neurotrophins, particularly in injury states, they point to the requirement for continued, local synthesis of BDNF to maintain optimal cardiac function. A major, unresolved question relates to how the truncated TrkB isoform (TrkBT1) transduces the inotropic effects of BDNF, which will require additional study. A concurrent study evaluated the potential impact of the BDNF-mediated activation of the kinase active isoform of TrkB in the adult heart, by genetically deleting this isoform in cardiac myocytes (Feng et al., 2014). Using this approach, deficits in CaMKII activity were observed upon deletion of kinase active TrkB. While deficits in systolic function were observed, these were not significant enough to trigger chamber dilation or reduce ejection fraction. Interestingly, in models of cardiac failure (induced by transverse aortic constriction, or in hearts overexpressing G α q that display cardiac dilation), induction of the truncated isoform (TrkBT1) is observed, suggesting a compensatory mechanism to augment myocyte contractility (Figure 1). These studies are highly relevant as the field considers the use of BDNF-mimetics to enhance TrkB activation in central neurons for the treatment of mood disorders, regulation of food intake, and neurod...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Publication date: Available online 4 April 2020Source: Physiology &BehaviorAuthor(s): Kuei-Pin Huang, Charlotte C. Ronveaux, Trina A. Knotts, Jennifer R. Rutkowsky, Jon J. Ramsey, Helen E. Raybould
Source: Physiology and Behavior - Category: Physiology Source Type: research
CONCLUSIONS: This study suggests that MTC is a more immunologically active tumor that has been previously reported. Patients with advanced MTC should be screened for targetable antigens and immune checkpoints to determine their eligibility for current clinical trials. Additional studies are necessary to fully characterize the antigenic potential of MTC and may encourage the development of adoptive T cells therapies for this rare tumor. PMID: 32242507 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Jerome Adams reaches for second world war imageryNo White House briefing as president tweets insteadCoronavirus – US updatesCoronavirus – global updatesSee all our coronavirus coverageThe US surgeon general warned the country on Sunday that it will face a “Pearl Harbor moment” in the next week, with an unprecedented numbers of coronavirus deaths expected coast to coast.Related:Jared Kushner and his shadow corona unit: what is Trump's son-in-law up to?Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Trump administration Donald Trump US news US politics World news US domestic policy Infectious diseases Science New York Andrew Cuomo Louisiana New Orleans Source Type: news
The influence of the α/β ratio on treatment time iso-effect relationships in the central nervous system. Int J Radiat Biol. 2020 Apr 03;:1-25 Authors: Jones B, Klinge T, Hopewell JW Abstract Purpose: To investigate the influence of changes in α/β ratio (range 1.5-3 Gy) on iso-effective doses, with varying treatment time, in spinal cord and central nervous system tissues with comparable radio-sensitivity. It is important to establish if an α/β ratio of 2 Gy, the accepted norm for neuro-oncology iso-effect estimations, can be used.Methods: The rat spinal cor...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Publication date: Available online 4 April 2020Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Maharsh K. Patel, William Z. Stone, Bradley S. Schoch, Aimee M. Struk, Kevin W. Farmer, Thomas W. Wright, Joseph J. King
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
A HEART attack can happen to anyone, anywhere, at any time. How do you know if you're at risk of having one? What's the sign in your eyes that could signal the deadly condition?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Almost 8,500 of the U.S. ’s reported 310,000 coronavirus patients have died, and governors are hunting for scarce ventilators. In Finland, a stockpile dating to the Cold War proves timely.
Source: NYT Health - Category: Consumer Health News Tags: Coronavirus (2019-nCoV) Source Type: news
In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional study was conducted on women with GH hospitalized in hospitals affiliated with Mashhad University of Medical Sciences, compared with healthy women admitted for normal delivery in the same centers during the study. Data were collected via Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) and Depression Anxiety Stress Scale (DASS) 21.Results: TEMPS-A revealed that scores anxious (P
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Conclusion: This study provides evidence for blood pressure management in Chinese pregnant women. PMID: 32243195 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Australia reported a sustained fall in new coronavirus infections and conducted the biggest peacetime maritime operation on Sydney Harbour on Saturday, refuelling foreign cruise ships before expelling them from local waters.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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