Association of gene polymorphisms in Anti-Müllerian hormone signaling pathway with ovarian function: a systematic review and meta-analysis

Publication date: Available online 26 April 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ran Cheng, Wei Xiong, Xiaoyan Luo, Yaxian Ma, Ying Nie, Xiaoyong Qiao, Hui Chen, Ying Hu, Liangzhi XuAbstractThe systematic review evaluated whether single nucleotide polymorphisms of AMH and AMHRII genes are associated with ovarian function. We searched literatures in PubMed and Embase complemented by hand search in the reference lists. Eight studies involving 3,155 participants were included in meta-analysis and 10 studies included for description. For AMH c.146T>G polymorphism, no significant difference in serum AMH levels was found between the participants with different genotypes (WMD=0.42, 95%CI=−0.16 to 0.99, P=0.156). The subgroup analysis by region and population showed a similar result. Regarding AMHRII −482 A>G, there was no significant difference in serum AMH levels between the participants with A/A genotype and G/A or G/G genotype carriers (WMD=-0.04, 95%CI=−0.31 to 0.23, P=0.775). In subgroup analysis, an interesting trend was confirmed in healthy women and PCOS patients (WMD=-0.36, 95%CI=−0.63 to -0.09, P=0.009; WMD=0.46, 95%CI=0.15 to 0.77, P=0.004). The review suggests that AMH c.146T>G is not associated with AMH levels, while AMHRII −482 A>G may be related to AMH levels in PCOS and healthy subgroups. However, the impact of polymorphisms in AMH signaling pathway on ovarian function still requires further investigations.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research