Mogamulizumab treatment elicits autoantibodies attacking the skin in patients with adult T cell leukemia-lymphoma.

CONCLUSIONS: Mogamulizumab elicits autoantibodies playing an important role in skin-related AE, possibly associated with regulatory T cell depletion. This is the first report demonstrating the presence of skin-directed autoantibodies after mogamulizumab treatment.
PMID: 31018922 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 23, 2019 Category: Cancer & Oncology Authors: Suzuki Y, Saito M, Ishii T, Urakawa I, Matsumoto A, Masaki A, Ito A, Kusumoto S, Suzuki S, Hiura M, Takahashi T, Morita A, Inagaki H, Iida S, Ishida T Tags: Clin Cancer Res Source Type: research