Mount Sinai researchers find significant delays in West Nile virus reporting

(The Mount Sinai Hospital / Mount Sinai School of Medicine) Mount Sinai researchers found significant delays in reporting human cases of West Nile virus, hampering real-time forecasting of the potentially deadly mosquito-borne disease, according to a study in the JAMA Network Open in April.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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uth Although West Nile virus (WNV) is generally thought to circulate among mosquitoes and birds, several historic and recent works providing evidence of WNV activity in wild mammals have been published. Indeed, a previous review tabulated evidence of WNV exposure in at least 100 mammalian species. Herein, we provide an update on WNV activity in wild and select other mammals that have been reported since the last major review article on this subject was published in early 2013. Of interest, new species, such as Hoffman’s two-toed sloths (Choloepus hoffmanni), are now included in the growing list of wild mammal...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Click arrow to play Download TWiV 547 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology arbovirus DDX68 epitranscriptome flavivirus hepatitis C virus mosquito vector viral viruses West Nile virus zika virus Source Type: blogs
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager, Rachel Netzband, and Alex Ciota Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Five postdocs in North America (TWiV 194) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Virol) (+) RNA virus epitranscriptome (Nucl Acids Res) Adaptation of Rabensburg virus to vertebrate ...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Contributors : Alexa B McIntyre ; Nandan S Gokhale ; Helen M Lazear ; Christopher L Holley ; Christopher E Mason ; Stacy M HornerSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe modification N6-methyladenosine (m6A) affects rates of translation and degradation of mRNA transcripts. We analyzed m6A across the transcriptome following infection by dengue virus (DENV), Zika virus (ZIKV), West Nile virus (WNV), and hepatitis C virus (HCV) using MeRIP-seq. We used the uninfected replicates, among which we would expect little biological variation in methylation, as negative control...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
Most of the world is at risk of being infected with a flavivirus such as dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, tickborne encephalitis virus, and Zika virus, significantly impacting millions of lives. Importantly, many of these genetically similar viruses co-circulate within the same geographic regions, making it likely for individuals living in areas of high flavivirus endemicity to be infected with multiple flaviviruses during their lifetime. Following a flavivirus infection, a robust virus-specific T cell response is generated and the memory recall of this response has been demon...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractIn both mice and humans, the CD8 T cell compartment is expanded with age in the presence of a cytomegalovirus (CMV) infection due to an absolute increase in the CD8+ T cell effector memory (TEM) cells. It has been hypothesized that in CMV+ subjects, such accumulated TEM cells could interfere with responses to new infection by competing for space/resources or could inhibit new responses by other, undefined, means. Here we present evidence against this hypothesis. We show that MCMV-specific CD8 T cells accumulate in blood and bone marrow, but not lymph nodes (frequent sites of immune response initiation), in either p...
Source: AGE - Category: Geriatrics Source Type: research
PMID: 31060643 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - Category: Neurology Authors: Tags: Can J Neurol Sci Source Type: research
Conclusions/SignificanceInvasiveAedes mosquitoes are established in certain locations of northeastern Turkey. Herein we conclusively show the role of these species in WNV circulation in the region. Biosurveillance is imperative to monitor the spread of these species further into Asia Minor and to detect possible introduction of pathogens.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This report highlights the catastrophic complications of WNV in an immunocompromised host.
Source: IDCases - Category: Infectious Diseases Source Type: research
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