Motor Timing in Tourette Syndrome: The Effect of Movement Lateralization and Bimanual Coordination

In conclusion, our study demonstrates that TS patients manifest “trait” abnormalities in the timing of sequential motor tasks, which are in keeping with the continuation phase of time processing, likely controlled by the sensorimotor loop of the cortico-basal ganglia network. We also show that the abnormal lateralization of fine motor control, previously reported in the context of the structural sequencing of fine motor tasks, extends also to motor timing accuracy. Finally, we highlight SMA connectivity as a potentially pivotal neural substrate of adaptive compensation of motor timing deficits in fine manual tasks in TS. We acknowledge that our results are based on a relatively small sample size. Another potential limitation is the lack of assessment for sub-diagnostic threshold ADHD symptomatology, although none of our TS patients had any history of current or past ADHD diagnosis. In this respect, future studies on larger samples should explore the presence of compensatory activation patterns using functional MRI, and correlate the level of this compensatory activation to the pattern of lateralization of motor timing abilities in TS patients. As for many other aspects of this complex neurodevelopmental disorder, longitudinal studies of multivariate datasets combining brain structure, brain performance and brain activation would have the potential to reveal the temporal trajectory of compensatory mechanisms that underlie phenotypic heterogeneity. Ethics Statement...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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The president ’s promises on health care stand in stark contrast with his legislative, regulatory and legal record.
Source: NYT - Category: American Health Authors: Tags: Patient Protection and Affordable Care Act (2010) Presidential Election of 2020 Trump, Donald J Health Insurance and Managed Care Executive Orders and Memorandums Regulation and Deregulation of Industry Source Type: news
Conclusion: IL-23 inhibitors are safe and efficacious therapeutic options for patients with psoriasis and should be considered as a potential first-line therapy alone or in combination with topical medications, phototherapy, and other systemic non-biologic agents. Consideration should be given to the evidence-based guidelines of global dermatologic organizations to help guide therapeutic decisions. PMID: 32962478 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Marques E, Paluch Z, Boháč P, Slanař O, Běláček J, Hercogová J Abstract INTRODUCTION: Understanding how different comorbidities and epidemiological factors are related to psoriasis severity can help us estimating patients' clinical outcome. AIM: Establish possible prognostic factors of severe psoriasis. METHODS: Three groups of patients were included: 118 were on topical therapy, 83 used conventional systemic drugs and 112 were treated with biological agents. Based of the fact that patients on topical therapy have a lower grade of disease severity than patients treated syst...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Lam PH, Hon KL, Leung K, Leong KF, Li CK, Leung TF Abstract BACKGROUND: Atopic eczema (AE) is a common relapsing inflammatory skin disease in children which is often associated with chronicity and poor quality of life. Unlike atopic asthma, control of AE is seldom assessed in therapeutics. AIM: To investigate the utility of a Traffic Light Control (TLC) system as a measurement/assessment of self-perceived eczema control. METHODS: This is a prospectively study of all Chinese children (aged 6 to 18 years old) with eczema attending the paediatric dermatology clinic of a tertiary hospital from Jan to J...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Publication date: Available online 23 September 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Igor Łoniewski, Agata Misera, Karolina Skonieczna-Żydecka, Mariusz Kaczmarczyk, Karolina Kaźmierczak-Siedlecka, Błażej Misiak, Wojciech Marlicz, Jerzy Samochowiec
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 23 September 2020Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Jensen Sanne, Hybel. Katja A, Højgaard. Davíð R, Nissen. Judith Becker, Skarphedinsson Gudmundur, Torp. Nor Christian, Ivarsson. Tord, Weidle. Bernhard, Mortensen. Erik Lykke, Carlsen. Anders Helles, Melin. Karin, Compton. Scott, Thomsen. Per Hove
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
This initiative aims to support the development and testing of systems-level interventions targeting high-risk youth to reduce or prevent suicide and suicidal behavior in these populations. Populations identified with high suicide risk and high unmet service need include but are not limited to: youth in public service systems, racial/ethnic minority youth, sexual and gender minority (SGM) youth, rural youth, and youth with intersectional risk. Relevant settings include but are not limited to: education or training programs, housing programs, juvenile justice, and child welfare.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
The primary objective of this Funding Opportunity Announcement (FOA) is to advance translational research to better understand risk and resilience for suicide in the context of the Research Domain Criteria (RDoC) framework and the Positive Valence Systems (PVS) domain.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
This FOA seeks to encourage research addressing major gaps identified in the United States Preventive Services Task Force (USPSTF) recommendation statement concerning interventions to prevent perinatal depression.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
To solicit pilot effectiveness projects that apply a mechanism-based approach to the development and evaluation of deployment-focused preschool Attention-deficit/hyperactivity disorder (ADHD) interventions. Relevant interventions could consider the unique challenges associated with treating ADHD symptoms and impairments in children under the age of six Interventions may also focus on preventing or forestalling the emergence of co-occurring disorders or additional ADHD symptoms and impairments that predictably emerge later in development.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
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