Healthy Body Weights With Corticosteroid-free Immunosuppression Is the Best Predictor of Cardiovascular Health in Children After Liver Transplantation
Introduction: Cardiometabolic dysregulation (CMD) influences morbidity and mortality risk in adults post-liver transplantation (LTx). CMD is reported in 10% to 25% of pediatric LTx recipients, but no information regarding the longitudinal expression of CMD is available. The study objective was to examine the longitudinal expression of CMD and associations with body composition and growth in children post-LTx. Methods: A retrospective review was conducted in youth (34 F/30 M) who underwent LTx between 1994 and 2015 at the Stollery Children's Hospital. Primary outcomes included serum markers of CMD (insulin, glucose, hemoglobin A1C [A1C], homeostasis model assessment for insulin resistance [abnormal>3], lipid panel triglycerides, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol) and systolic/diastolic blood pressure (BP: absolute/z scores). Results: Mean (±SD) age, weight z, height z, body mass index z was 9.7 ± 3.4 years (3.5–17.9), 0.26 ± 1.03, 0.017 ± 1.2, and 0.41 ± 1.05, respectively. The majority of children had percentage fat mass, percentage fat-free mass within normal reference ranges. Systolic/diastolic BP was within healthy references ranges in 83.1% and 93.5% of children, respectively. Serum insulin (83.4%) and high-density lipoprotein-cholesterol (43.9%) concentrations were low, with abnormal findings of other laboratory markers found in
STATINS can prevent liver cancer, according to a new study.
Condition: Lipid Metabolism Disorders Intervention: Sponsors: University of Texas Southwestern Medical Center; National Heart, Lung, and Blood Institute (NHLBI) Enrolling by invitation
SUPPLEMENTS can help to ward off a range of potentially life-threatening ailments. Growing evidence suggests that certain supplements can reduce high cholesterol, including this natural remedy.
MONDAY, Aug. 19, 2019 (American Heart Association News) -- Women are less likely than men to be treated with cholesterol-lowering statins– or get them prescribed at guideline-recommended intensity levels when they do, according to a new study...
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.9b04967
The administration of geranylgeranyl pyrophosphate (GGPP) (or its precursor, geranylgeraniol) has been shown by several in vitro studies to be capable of abrogating statin-induced myotoxicity. Nonetheless, the potential of GGPP repletion to prevent statin-associated muscle symptoms (SAMS) in vivo is yet to be investigated. Therefore, this study aimed to evaluate the ability of geranylgeraniol (GGOH) to prevent SAMS in rodents. Female Wistar rats (12 weeks of age) were randomised to one of four treatment groups: control, control with GGOH, simvastatin or simvastatin with GGOH.
Cell Death &Disease, Published online: 19 August 2019; doi:10.1038/s41419-019-1858-9Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity
Publication date: Available online 25 July 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Sophy Korula, Sumita Danda, Praveen G. Paul, Sarah Mathai, Anna SimonBackgroundGlycogen storage disease (GSD) is typified by early morning seizures. Absence of this results in delayed diagnosis, especially the non-GSD 1 group. Data are limited to few patients with unclear outcome.Objectives1. Study the common presentation and types of GSD. 2. Study the clinical and biochemical outcome. 3. Review genetic mutations.MethodsObservational study from May 2016–April 2019 at metabolic clinic at our cente...
CONCLUSION: ATV inhibited ROS generation and activated IL-1 β/IL-6 secretion in PBMNC of diabetes patients. Its effect was not affected by the hyperglymemia. PMID: 31416412 [PubMed - as supplied by publisher]
Publication date: Available online 16 August 2019Source: Journal of Sport and Health ScienceAuthor(s): Carlos Cristi-Montero, Javier Courel-Ibáñez, Francisco B Ortega, Jose Castro-Piñero, Alba Santaliestra Pasias, Angela Polito, Jérémy Vanhelst, Ascensión Marcos, Luis M Moreno, Jonatan R Ruiz, HELENA study groupAbstractPurposeTo analyze the mediation role of cardiorespiratory fitness (CRF) on the association between fatness and cardiometabolic risk (CMRs) in European adolescents.MethodsA cross-sectional study was conducted in adolescents (n = 525; boys 46%; 14.1 ± 1.1 ye...