Individualization of FSH Doses in Assisted Reproduction: Facts and Fiction

Individualization of FSH Doses in Assisted Reproduction: Facts and Fiction Frank J. Broekmans* University Medical Center Utrecht, Utrecht, Netherlands The art of ovarian stimulation for IVF/ICSI treatment using exogenous FSH should be balanced against the relative contribution of other steps of the ART process such as the IVF-lab-phase and the Embryo-Transfer. The aim of ovarian stimulation is to obtain a certain number of oocytes, that will enable the best probability of achieving a live birth. It has been suggested that more oocytes will create a better prospect for pregnancy, but studies on the question whether the retrieval of a few oocytes less or more will make the difference are not clearly supportive for this mantra. Personalization strategies have been the subject of many studies over the past 20 years. Creating the optimal response in a patient in terms of live birth prognosis as well as OHSS risks may be based on information from the Ovarian Reserve testing using the Antral Follicle Count or Anti-Mullerian Hormone, the patient's bodyweight, the ovarian response in a previous cycle, and the dosage level of FSH. Taken together, steering the ovarian response into a supposed optimal range may appear difficult as the interrelation for each of these factors with the egg number is weak. Using OR testing for choosing FSH dosage, compared to a standard normal dosage of 150 IU, has been studied in several trials. Dosage individualization, in general, does no...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

Related Links:

CONCLUSION: Pregnancy outcomes after hysteroscopic placement of a microinsert for hydrosalpinx management before embryo transfer were comparable to those following laparoscopic proximal tubal occlusion or salpingectomy. However, caution is advised regarding microinsert placement for hydrosalpinges before proceeding with assisted reproductive technology. PMID: 32224160 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Authors: Feres M, Retamal-Valdes B, Faveri M, Duarte P, Shibli J, Soares GMS, Miranda T, Teles F, Goodson M, Hasturk H, Van Dyke T, Ehmke B, Eickholz P, Schlagenhauf U, Meyle J, Koch R, Kocher T, Hoffmann T, Kim TS, Kaner D, Figueiredo LC, Doyle H Abstract OBJECTIVE: The selection of proper outcome measures is a critical step in clinical research. Most randomized clinical trials (RCTs) assessing the effects of initial anti-infective periodontal therapies use surrogate outcomes as primary outcome variables, such as mean changes in probing depth (PD) or in clinical attachment. However, these parameters do not reflect...
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
Authors: Lee Y, Ahn EH, Ryu CS, Kim JO, An HJ, Cho SH, Kim JH, Kim YR, Lee WS, Kim NK Abstract The present study aimed to investigate the potential association of five miRNA machinery gene polymorphisms (DICER1 rs3742330A>G, DROSHA rs10719T>C, RAN rs14035C>T, XPO5 rs11077A>C and DGCR8 rs417309G>A) with recurrent implantation failure (RIF), a clinical condition in which good-quality embryos repeatedly fail to implant following two or more in vitro fertilization cycles, and its associated risk factors in Korean women. Therefore, the present study performed genotype analysis and assessed the frequency o...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
NIEHS researchers found that newborn mice exposed to genistein, which mimics estrogen in the body, experienced pregnancy failure as adults. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news
Authors: Torretta S, Gaini LM, Pignataro L PMID: 32225995 [PubMed - as supplied by publisher]
Source: Acta Otorhinolaryngologica Italica - Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research
Sarah Boseley speaks toProf Sonja Rasmussen about how the virus might affect mothers who are expecting and their unborn childContinue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Coronavirus outbreak Pregnancy Parents and parenting Infectious diseases Biology Medical research Childbirth Source Type: news
This study consists of a case series describing 13 single pregnancies of 11 women with a history of anorexia nervosa, and a cross-sectional study comparing 13 cases with 240 healthy controls. In the case group, nine cases conceived while underweight, including three who had fertility treatment. Anorexia symptoms during pregnancy were quite common, and pregnant smokers presented with extremely disturbed eating behaviors. In a cross-sectional study, premature birth and the standard deviations from the mean birth weight and mean head circumference at birth were evaluated as outcome measures. The adjusted odds ratios or the ad...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Conclusions: This study shows significant differences between both insertion techniques regarding correct graft orientation directly after graft implantation leading to prolonged insertion-to-attachment time when the graft is flushed instead of pushed into the anterior chamber.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Conclusions: The use of this repeatable technique to harvest and transplant an autologous DSAEK graft eliminates endothelial rejection in high-risk eyes.
Source: Cornea - Category: Opthalmology Tags: Techniques Source Type: research
Conclusions and discussion: There is value to using a common template to provide guidance in international comparison of models of integrated care. We discuss the applicability of the approach to support scale and spread of integrated care internationally. Published on 2020-04-01 15:13:44
Source: International Journal of Integrated Care - Category: Nursing Source Type: research
More News: Academia | Allegra | Amenorrhea | Atresia | Babies | Belgium Health | Biotechnology | Child Development | Children | Clinical Trials | Databases & Libraries | Education | Endocrinology | Estradiol | Genetics | Germany Health | Hormones | ICSI (Intracytoplasmic Sperm Injection) | Infertility | Italy Health | IVF (in vitro fertilisation) | Laboratory Medicine | Men | Merck | Netherlands Health | Ovaries | Polycystic Ovary Syndrome | Pregnancy | Reproduction Medicine | Study | Ultrasound | Women